Costa PR - Search Results

1

Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom.

da Silva AJ, Coelho AL, Simas AB, Moraes RA, Pinheiro DA, Fernandes FF, Arruda EZ, Costa PR, Melo PA. da Silva AJ, et al. Among authors: costa pr. Bioorg Med Chem Lett. 2004 Jan 19;14(2):431-5. doi: 10.1016/j.bmcl.2003.10.044. Bioorg Med Chem Lett. 2004. PMID: 14698175

2

Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.

da Silva AJ, Buarque CD, Brito FV, Aurelian L, Macedo LF, Malkas LH, Hickey RJ, Lopes DV, Noël F, Murakami YL, Silva NM, Melo PA, Caruso RR, Castro NG, Costa PR. da Silva AJ, et al. Among authors: costa pr. Bioorg Med Chem. 2002 Aug;10(8):2731-8. doi: 10.1016/s0968-0896(02)00100-1. Bioorg Med Chem. 2002. PMID: 12057662

3

Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor.

Lopes DV, Caruso RR, Castro NG, Costa PR, da Silva AJ, Noël F. Lopes DV, et al. Among authors: costa pr. Eur J Pharmacol. 2004 Jul 14;495(2-3):87-96. doi: 10.1016/j.ejphar.2004.05.026. Eur J Pharmacol. 2004. PMID: 15249156

4

Stereoselective synthesis and preliminary evaluation of new D-3-heteroarylcarbonylalanines as ligands of the NMDA receptor.

Lima PG, Caruso RR, Alves SO, Pessôa RF, Mendonça-Silva DL, Nunes RJ, Noël F, Castro NG, Costa PR. Lima PG, et al. Among authors: costa pr. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4399-403. doi: 10.1016/j.bmcl.2004.06.062. Bioorg Med Chem Lett. 2004. PMID: 15357961

5

Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor.

Pôças ES, Lopes DV, da Silva AJ, Pimenta PH, Leitão FB, Netto CD, Buarque CD, Brito FV, Costa PR, Noël F. Pôças ES, et al. Among authors: costa pr. Bioorg Med Chem. 2006 Dec 1;14(23):7962-6. doi: 10.1016/j.bmc.2006.07.053. Epub 2006 Aug 30. Bioorg Med Chem. 2006. PMID: 16945543

6

Synergistic interaction between ouabain and 8-methoxy-3,9-dihydroxy coumestan, a non-steroidal synthetic inhibitor of Na+,K+-ATPase.

Pôças ES, Touza NA, da Silva AJ, Costa PR, Noël F. Pôças ES, et al. Among authors: costa pr. Life Sci. 2007 Sep 22;81(15):1199-204. doi: 10.1016/j.lfs.2007.08.021. Epub 2007 Aug 28. Life Sci. 2007. PMID: 17884104

7

(+/-)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: cytotoxic effect on human leukemia cell lines.

Netto CD, Santos ES, Castro CP, da Silva AJ, Rumjanek VM, Costa PR. Netto CD, et al. Among authors: costa pr. Eur J Med Chem. 2009 Feb;44(2):920-5. doi: 10.1016/j.ejmech.2008.01.027. Epub 2008 Feb 2. Eur J Med Chem. 2009. PMID: 18468732

8

Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan.

Pôças ES, Touza NA, Pimenta PH, Leitão FB, Neto CD, da Silva AJ, Costa PR, Noël F. Pôças ES, et al. Among authors: costa pr. Bioorg Med Chem. 2008 Oct 1;16(19):8801-5. doi: 10.1016/j.bmc.2008.09.007. Epub 2008 Sep 7. Bioorg Med Chem. 2008. PMID: 18805699

9

Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells.

Salustiano EJ, Netto CD, Fernandes RF, da Silva AJ, Bacelar TS, Castro CP, Buarque CD, Maia RC, Rumjanek VM, Costa PR. Salustiano EJ, et al. Among authors: costa pr. Invest New Drugs. 2010 Apr;28(2):139-44. doi: 10.1007/s10637-009-9231-y. Epub 2009 Mar 4. Invest New Drugs. 2010. PMID: 19255723

10

N-tert-butyl and N-methyl nitrones derived from aromatic aldehydes inhibit macromolecular permeability increase induced by ischemia/reperfusion in hamsters.

Dias AG, Santos CE, Cyrino FZ, Bouskela E, Costa PR. Dias AG, et al. Among authors: costa pr. Bioorg Med Chem. 2009 Jun 1;17(11):3995-8. doi: 10.1016/j.bmc.2009.04.004. Epub 2009 Apr 8. Bioorg Med Chem. 2009. PMID: 19410467

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