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CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.
Elzein E, Ibrahim P, Koltun DO, Rehder K, Shenk KD, Marquart TA, Jiang B, Li X, Natero R, Li Y, Nguyen M, Kerwar S, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Zeng D, Leung K, Zablocki JA. Elzein E, et al. Among authors: hao j. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6017-21. doi: 10.1016/j.bmcl.2004.09.077. Bioorg Med Chem Lett. 2004. PMID: 15546720
Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Koltun DO, Vasilevich NI, Parkhill EQ, Glushkov AI, Zilbershtein TM, Mayboroda EI, Boze MA, Cole AG, Henderson I, Zautke NA, Brunn SA, Chu N, Hao J, Mollova N, Leung K, Chisholm JW, Zablocki J. Koltun DO, et al. Among authors: hao j. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3050-3. doi: 10.1016/j.bmcl.2009.04.004. Epub 2009 Apr 8. Bioorg Med Chem Lett. 2009. PMID: 19394219
Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Koltun DO, Zilbershtein TM, Migulin VA, Vasilevich NI, Parkhill EQ, Glushkov AI, McGregor MJ, Brunn SA, Chu N, Hao J, Mollova N, Leung K, Chisholm JW, Zablocki J. Koltun DO, et al. Among authors: hao j. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. doi: 10.1016/j.bmcl.2009.06.017. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19577469
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Zhang L, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG. Wen X, et al. Among authors: hao j. J Med Chem. 2008 Jun 26;51(12):3540-54. doi: 10.1021/jm8000949. Epub 2008 Jun 3. J Med Chem. 2008. PMID: 18517260
7,348 results