Zablocki JA - Search Results

1

New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties.

Koltun DO, Marquart TA, Shenk KD, Elzein E, Li Y, Nguyen M, Kerwar S, Zeng D, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Ng KJ, Fraser H, Zablocki JA. Koltun DO, et al. Among authors: zablocki ja. Bioorg Med Chem Lett. 2004 Jan 19;14(2):549-52. doi: 10.1016/j.bmcl.2003.09.093. Bioorg Med Chem Lett. 2004. PMID: 14698201

2

Novel inhibitors of fatty acid oxidation as potential metabolic modulators.

Elzein E, Shenk K, Ibrahim P, Marquart T, Kerwar S, Meyer S, Ahmed H, Zeng D, Chu N, Soohoo D, Wong S, Leung K, Zablocki J. Elzein E, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):973-7. doi: 10.1016/j.bmcl.2003.11.065. Bioorg Med Chem Lett. 2004. PMID: 15013004

3

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.

Koltun DO, Vasilevich NI, Parkhill EQ, Glushkov AI, Zilbershtein TM, Mayboroda EI, Boze MA, Cole AG, Henderson I, Zautke NA, Brunn SA, Chu N, Hao J, Mollova N, Leung K, Chisholm JW, Zablocki J. Koltun DO, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3050-3. doi: 10.1016/j.bmcl.2009.04.004. Epub 2009 Apr 8. Bioorg Med Chem Lett. 2009. PMID: 19394219

4

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.

Koltun DO, Zilbershtein TM, Migulin VA, Vasilevich NI, Parkhill EQ, Glushkov AI, McGregor MJ, Brunn SA, Chu N, Hao J, Mollova N, Leung K, Chisholm JW, Zablocki J. Koltun DO, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. doi: 10.1016/j.bmcl.2009.06.017. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19577469

5

Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.

Morrison CF, Elzein E, Jiang B, Ibrahim PN, Marquart T, Palle V, Shenk KD, Varkhedkar V, Maa T, Wu L, Wu Y, Zeng D, Fong I, Lustig D, Leung K, Zablocki JA. Morrison CF, et al. Among authors: zablocki ja. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3793-7. doi: 10.1016/j.bmcl.2004.04.096. Bioorg Med Chem Lett. 2004. PMID: 15203164

6

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.

Elzein E, Ibrahim P, Koltun DO, Rehder K, Shenk KD, Marquart TA, Jiang B, Li X, Natero R, Li Y, Nguyen M, Kerwar S, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Zeng D, Leung K, Zablocki JA. Elzein E, et al. Among authors: zablocki ja. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6017-21. doi: 10.1016/j.bmcl.2004.09.077. Bioorg Med Chem Lett. 2004. PMID: 15546720

7

2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.

Elzein E, Palle V, Wu Y, Maa T, Zeng D, Zablocki J. Elzein E, et al. J Med Chem. 2004 Sep 9;47(19):4766-73. doi: 10.1021/jm049682h. J Med Chem. 2004. PMID: 15341491

8

The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.

Zablocki J, Kalla R, Perry T, Palle V, Varkhedkar V, Xiao D, Piscopio A, Maa T, Gimbel A, Hao J, Chu N, Leung K, Zeng D. Zablocki J, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):609-12. doi: 10.1016/j.bmcl.2004.11.044. Bioorg Med Chem Lett. 2005. PMID: 15664822

9

Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.

Elzein E, Kalla R, Li X, Perry T, Parkhill E, Palle V, Varkhedkar V, Gimbel A, Zeng D, Lustig D, Leung K, Zablocki J. Elzein E, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):302-6. doi: 10.1016/j.bmcl.2005.10.002. Epub 2005 Nov 4. Bioorg Med Chem Lett. 2006. PMID: 16275090

10

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Kalla RV, Elzein E, Perry T, Li X, Palle V, Varkhedkar V, Gimbel A, Maa T, Zeng D, Zablocki J. Kalla RV, et al. J Med Chem. 2006 Jun 15;49(12):3682-92. doi: 10.1021/jm051268+. J Med Chem. 2006. PMID: 16759111

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