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The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM. Scanlan CN, et al. Among authors: pantophlet r. Adv Exp Med Biol. 2003;535:205-18. doi: 10.1007/978-1-4615-0065-0_13. Adv Exp Med Biol. 2003. PMID: 14714897 No abstract available.
GP120: target for neutralizing HIV-1 antibodies.
Pantophlet R, Burton DR. Pantophlet R, et al. Annu Rev Immunol. 2006;24:739-69. doi: 10.1146/annurev.immunol.24.021605.090557. Annu Rev Immunol. 2006. PMID: 16551265 Review.
Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. Saphire EO, et al. Among authors: pantophlet r. J Mol Biol. 2007 Jun 8;369(3):696-709. doi: 10.1016/j.jmb.2007.01.060. Epub 2007 Jan 27. J Mol Biol. 2007. PMID: 17445828 Free PMC article.
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
Astronomo RD, Lee HK, Scanlan CN, Pantophlet R, Huang CY, Wilson IA, Blixt O, Dwek RA, Wong CH, Burton DR. Astronomo RD, et al. Among authors: pantophlet r. J Virol. 2008 Jul;82(13):6359-68. doi: 10.1128/JVI.00293-08. Epub 2008 Apr 23. J Virol. 2008. PMID: 18434393 Free PMC article.
65 results