Kortum RL - Search Results

1

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.

Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA. Matheny SA, et al. Among authors: kortum rl. Nature. 2004 Jan 15;427(6971):256-60. doi: 10.1038/nature02237. Nature. 2004. PMID: 14724641

2

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma.

Daley BR, Sealover NE, Sheffels E, Hughes JM, Gerlach D, Hofmann MH, Kostyrko K, Mair B, Linke A, Beckley Z, Frank A, Dalgard C, Kortum RL. Daley BR, et al. Among authors: kortum rl. bioRxiv [Preprint]. 2023 Dec 15:2023.12.07.570642. doi: 10.1101/2023.12.07.570642. bioRxiv. 2023. Update in: Cancer Res. 2025 Jan 2;85(1):118-133. doi: 10.1158/0008-5472.CAN-23-3256 PMID: 38106234 Free PMC article. Updated. Preprint.

3

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.

Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Nguyen A, et al. Mol Cell Biol. 2002 May;22(9):3035-45. doi: 10.1128/MCB.22.9.3035-3045.2002. Mol Cell Biol. 2002. PMID: 11940661 Free PMC article.

4

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells.

Kortum RL, Lewis RE. Kortum RL, et al. Mol Cell Biol. 2004 May;24(10):4407-16. doi: 10.1128/MCB.24.10.4407-4416.2004. Mol Cell Biol. 2004. PMID: 15121859 Free PMC article.

5

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation.

Razidlo GL, Kortum RL, Haferbier JL, Lewis RE. Razidlo GL, et al. Among authors: kortum rl. J Biol Chem. 2004 Nov 12;279(46):47808-14. doi: 10.1074/jbc.M406395200. Epub 2004 Sep 13. J Biol Chem. 2004. PMID: 15371409 Free article.

6

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity.

Kim M, Yan Y, Kortum RL, Stoeger SM, Sgagias MK, Lee K, Lewis RE, Cowan KH. Kim M, et al. Among authors: kortum rl. Cancer Res. 2005 May 15;65(10):3986-92. doi: 10.1158/0008-5472.CAN-03-2334. Cancer Res. 2005. PMID: 15899786

7

The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis.

Kortum RL, Costanzo DL, Haferbier J, Schreiner SJ, Razidlo GL, Wu MH, Volle DJ, Mori T, Sakaue H, Chaika NV, Chaika OV, Lewis RE. Kortum RL, et al. Mol Cell Biol. 2005 Sep;25(17):7592-604. doi: 10.1128/MCB.25.17.7592-7604.2005. Mol Cell Biol. 2005. PMID: 16107706 Free PMC article.

8

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.

Kortum RL, Johnson HJ, Costanzo DL, Volle DJ, Razidlo GL, Fusello AM, Shaw AS, Lewis RE. Kortum RL, et al. Mol Cell Biol. 2006 Mar;26(6):2202-14. doi: 10.1128/MCB.26.6.2202-2214.2006. Mol Cell Biol. 2006. PMID: 16507997 Free PMC article.

9

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE. Costanzo-Garvey DL, et al. Among authors: kortum rl. Cell Metab. 2009 Nov;10(5):366-78. doi: 10.1016/j.cmet.2009.09.010. Cell Metab. 2009. PMID: 19883615 Free PMC article.

10

Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth.

Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE. Fisher KW, et al. Among authors: kortum rl. Mol Cell Biol. 2011 Jun;31(12):2453-61. doi: 10.1128/MCB.05255-11. Epub 2011 Apr 25. Mol Cell Biol. 2011. PMID: 21518958 Free PMC article.

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