van Aalten DM - Search Results

1

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.

Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM. Milburn CC, et al. Among authors: van aalten dm. Nat Struct Mol Biol. 2004 Feb;11(2):193-200. doi: 10.1038/nsmb716. Epub 2004 Jan 18. Nat Struct Mol Biol. 2004. PMID: 14730349

2

Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold.

van Aalten DM, DiRusso CC, Knudsen J, Wierenga RK. van Aalten DM, et al. EMBO J. 2000 Oct 2;19(19):5167-77. doi: 10.1093/emboj/19.19.5167. EMBO J. 2000. PMID: 11013219 Free PMC article.

3

Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein.

van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA. van Aalten DM, et al. J Mol Biol. 2001 May 25;309(1):181-92. doi: 10.1006/jmbi.2001.4749. J Mol Biol. 2001. PMID: 11491287

4

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Biochem J. 2001 Sep 1;358(Pt 2):287-94. doi: 10.1042/0264-6021:3580287. Biochem J. 2001. PMID: 11513726 Free PMC article.

5

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM. Biondi RM, et al. Among authors: van aalten dm. EMBO J. 2002 Aug 15;21(16):4219-28. doi: 10.1093/emboj/cdf437. EMBO J. 2002. PMID: 12169624 Free PMC article.

6

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.

Thomas CC, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Curr Biol. 2002 Jul 23;12(14):1256-62. doi: 10.1016/s0960-9822(02)00972-7. Curr Biol. 2002. PMID: 12176338 Free article.

7

High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.

Alphey MS, Attrill H, Crocker PR, van Aalten DM. Alphey MS, et al. Among authors: van aalten dm. J Biol Chem. 2003 Jan 31;278(5):3372-7. doi: 10.1074/jbc.M210602200. Epub 2002 Nov 15. J Biol Chem. 2003. PMID: 12438315 Free article.

8

Crystal structures of allosamidin derivatives in complex with human macrophage chitinase.

Rao FV, Houston DR, Boot RG, Aerts JM, Sakuda S, van Aalten DM. Rao FV, et al. Among authors: van aalten dm. J Biol Chem. 2003 May 30;278(22):20110-6. doi: 10.1074/jbc.M300362200. Epub 2003 Mar 14. J Biol Chem. 2003. PMID: 12639956 Free article.

9

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Among authors: van aalten dm. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.

10

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM. Milburn CC, et al. Among authors: van aalten dm. Biochem J. 2003 Nov 1;375(Pt 3):531-8. doi: 10.1042/BJ20031229. Biochem J. 2003. PMID: 12964941 Free PMC article.

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