Tam EM - Search Results

1

The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily.

Butler GS, Tam EM, Overall CM. Butler GS, et al. Among authors: tam em. J Biol Chem. 2004 Apr 9;279(15):15615-20. doi: 10.1074/jbc.M312727200. Epub 2004 Jan 19. J Biol Chem. 2004. PMID: 14732714 Free article.

2

Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage.

Tam EM, Wu YI, Butler GS, Stack MS, Overall CM. Tam EM, et al. J Biol Chem. 2002 Oct 11;277(41):39005-14. doi: 10.1074/jbc.M206874200. Epub 2002 Jul 26. J Biol Chem. 2002. PMID: 12145314 Free article.

3

Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.

Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente X, López-Otín C, Seth A. Overall CM, et al. Among authors: tam em. Biol Chem. 2004 Jun;385(6):493-504. doi: 10.1515/BC.2004.058. Biol Chem. 2004. PMID: 15255181

4

Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities.

Tam EM, Moore TR, Butler GS, Overall CM. Tam EM, et al. J Biol Chem. 2004 Oct 8;279(41):43336-44. doi: 10.1074/jbc.M407186200. Epub 2004 Aug 2. J Biol Chem. 2004. PMID: 15292230 Free article.

5

Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency.

Butler GS, Sim D, Tam E, Devine D, Overall CM. Butler GS, et al. J Biol Chem. 2002 May 17;277(20):17511-9. doi: 10.1074/jbc.M201461200. Epub 2002 Mar 12. J Biol Chem. 2002. PMID: 11891230 Free article.

6

Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation.

Overall CM, Tam E, McQuibban GA, Morrison C, Wallon UM, Bigg HF, King AE, Roberts CR. Overall CM, et al. J Biol Chem. 2000 Dec 15;275(50):39497-506. doi: 10.1074/jbc.M005932200. J Biol Chem. 2000. PMID: 10991943 Free article.

7

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates.

Tam EM, Morrison CJ, Wu YI, Stack MS, Overall CM. Tam EM, et al. Proc Natl Acad Sci U S A. 2004 May 4;101(18):6917-22. doi: 10.1073/pnas.0305862101. Epub 2004 Apr 26. Proc Natl Acad Sci U S A. 2004. PMID: 15118097 Free PMC article.

8

Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.

Butler GS, Dean RA, Tam EM, Overall CM. Butler GS, et al. Among authors: tam em. Mol Cell Biol. 2008 Aug;28(15):4896-914. doi: 10.1128/MCB.01775-07. Epub 2008 May 27. Mol Cell Biol. 2008. PMID: 18505826 Free PMC article.

9

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. McQuibban GA, et al. Among authors: tam em. Science. 2000 Aug 18;289(5482):1202-6. doi: 10.1126/science.289.5482.1202. Science. 2000. PMID: 10947989

10

Identification of the TIMP-2 binding site on the gelatinase A hemopexin C-domain by site-directed mutagenesis and the yeast two-hybrid system.

Overall CM, King AE, Bigg HF, McQuibban A, Atherstone J, Sam DK, Ong AD, Lau TT, Wallon UM, DeClerck YA, Tam E. Overall CM, et al. Ann N Y Acad Sci. 1999 Jun 30;878:747-53. doi: 10.1111/j.1749-6632.1999.tb07780.x. Ann N Y Acad Sci. 1999. PMID: 10415826 No abstract available.

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