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Page 1
Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.
Dyatkin AB, Hoekstra WJ, Kinney WA, Kontoyianni M, Santulli RJ, Kimball ES, Fisher MC, Prouty SM, Abraham WM, de Garavilla L, Andrade-Gordon P, Hlasta DJ, He W, Hornby PJ, Damiano BP, Maryanoff BE. Dyatkin AB, et al. Among authors: kinney wa. Bioorg Med Chem Lett. 2004 Feb 9;14(3):591-6. doi: 10.1016/j.bmcl.2003.11.063. Bioorg Med Chem Lett. 2004. PMID: 14741249
Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.
De Corte BL, Kinney WA, Liu L, Ghosh S, Brunner L, Hoekstra WJ, Santulli RJ, Tuman RW, Baker J, Burns C, Proost JC, Tounge BA, Damiano BP, Maryanoff BE, Johnson DL, Galemmo RA Jr. De Corte BL, et al. Among authors: kinney wa. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. doi: 10.1016/j.bmcl.2004.06.061. Bioorg Med Chem Lett. 2004. PMID: 15380233
1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability.
Ghosh S, Santulli RJ, Kinney WA, Decorte BL, Liu L, Lewis JM, Proost JC, Leo GC, Masucci J, Hageman WE, Thompson AS, Chen I, Kawahama R, Tuman RW, Galemmo RA Jr, Johnson DL, Damiano BP, Maryanoff BE. Ghosh S, et al. Among authors: kinney wa. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. doi: 10.1016/j.bmcl.2004.08.067. Bioorg Med Chem Lett. 2004. PMID: 15501072
Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists.
Dyatkin AB, Gong Y, Miskowski TA, Kimball ES, Prouty SM, Fisher MC, Santulli RJ, Schneider CR, Wallace NH, Hornby PJ, Diamond C, Kinney WA, Maryanoff BE, Damiano BP, He W. Dyatkin AB, et al. Among authors: kinney wa. Bioorg Med Chem. 2005 Dec 15;13(24):6693-702. doi: 10.1016/j.bmc.2005.07.022. Epub 2005 Aug 19. Bioorg Med Chem. 2005. PMID: 16112583
Urotensin-II receptor modulators as potential drugs.
Maryanoff BE, Kinney WA. Maryanoff BE, et al. Among authors: kinney wa. J Med Chem. 2010 Apr 8;53(7):2695-708. doi: 10.1021/jm901294u. J Med Chem. 2010. PMID: 20043680 Review. No abstract available.
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
Santulli RJ, Kinney WA, Ghosh S, Decorte BL, Liu L, Tuman RW, Zhou Z, Huebert N, Bursell SE, Clermont AC, Grant MB, Shaw LC, Mousa SA, Galemmo RA Jr, Johnson DL, Maryanoff BE, Damiano BP. Santulli RJ, et al. Among authors: kinney wa. J Pharmacol Exp Ther. 2008 Mar;324(3):894-901. doi: 10.1124/jpet.107.131656. Epub 2007 Dec 14. J Pharmacol Exp Ther. 2008. PMID: 18083913
Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies.
Kinney WA, Teleha CA, Thompson AS, Newport M, Hansen R, Ballentine S, Ghosh S, Mahan A, Grasa G, Zanotti-Gerosa A, Dingenen J, Schubert C, Zhou Y, Leo GC, McComsey DF, Santulli RJ, Maryanoff BE. Kinney WA, et al. J Org Chem. 2008 Mar 21;73(6):2302-10. doi: 10.1021/jo702551t. Epub 2008 Feb 16. J Org Chem. 2008. PMID: 18278942
40 results