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Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant.
Ragno R, Mai A, Sbardella G, Artico M, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, La Colla P. Ragno R, et al. Among authors: cadeddu a. J Med Chem. 2004 Feb 12;47(4):928-34. doi: 10.1021/jm0309856. J Med Chem. 2004. PMID: 14761194
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family.
Mai A, Artico M, Ragno R, Sbardella G, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, Maga G, La Colla P. Mai A, et al. Among authors: cadeddu a. Bioorg Med Chem. 2005 Mar 15;13(6):2065-77. doi: 10.1016/j.bmc.2005.01.005. Bioorg Med Chem. 2005. PMID: 15727860
2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.
Benzaria S, Bardiot D, Bouisset T, Counor C, Rabeson C, Pierra C, Storer R, Loi AG, Cadeddu A, Mura M, Musiu C, Liuzzi M, Loddo R, Bergelson S, Bichko V, Bridges E, Cretton-Scott E, Mao J, Sommadossi JP, Seifer M, Standring D, Tausek M, Gosselin G, La Colla P. Benzaria S, et al. Among authors: cadeddu a. Antivir Chem Chemother. 2007;18(4):225-42. doi: 10.1177/095632020701800406. Antivir Chem Chemother. 2007. PMID: 17907380 Free article.
16 results