Kobayashi A - Search Results

1

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.

Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M. Kang MI, et al. Among authors: kobayashi a. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2046-51. doi: 10.1073/pnas.0308347100. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764898 Free PMC article.

2

Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.

Kobayashi A, Ohta T, Yamamoto M. Kobayashi A, et al. Methods Enzymol. 2004;378:273-86. doi: 10.1016/S0076-6879(04)78021-0. Methods Enzymol. 2004. PMID: 15038975 Review. No abstract available.

3

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M. Kobayashi A, et al. Mol Cell Biol. 2004 Aug;24(16):7130-9. doi: 10.1128/MCB.24.16.7130-7139.2004. Mol Cell Biol. 2004. PMID: 15282312 Free PMC article.

4

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M. Katoh Y, et al. Among authors: kobayashi a. Arch Biochem Biophys. 2005 Jan 15;433(2):342-50. doi: 10.1016/j.abb.2004.10.012. Arch Biochem Biophys. 2005. PMID: 15581590 Review.

5

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.

Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M. Kobayashi A, et al. Mol Cell Biol. 2006 Jan;26(1):221-9. doi: 10.1128/MCB.26.1.221-229.2006. Mol Cell Biol. 2006. PMID: 16354693 Free PMC article.

6

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Among authors: kobayashi a. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.

7

Identification of polymorphisms in the promoter region of the human NRF2 gene.

Yamamoto T, Yoh K, Kobayashi A, Ishii Y, Kure S, Koyama A, Sakamoto T, Sekizawa K, Motohashi H, Yamamoto M. Yamamoto T, et al. Among authors: kobayashi a. Biochem Biophys Res Commun. 2004 Aug 13;321(1):72-9. doi: 10.1016/j.bbrc.2004.06.112. Biochem Biophys Res Commun. 2004. PMID: 15358217

8

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Okawa H, et al. Among authors: kobayashi a. Biochem Biophys Res Commun. 2006 Jan 6;339(1):79-88. doi: 10.1016/j.bbrc.2005.10.185. Epub 2005 Nov 8. Biochem Biophys Res Commun. 2006. PMID: 16293230

9

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.

Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Padmanabhan B, et al. Among authors: kobayashi a. Mol Cell. 2006 Mar 3;21(5):689-700. doi: 10.1016/j.molcel.2006.01.013. Mol Cell. 2006. PMID: 16507366 Free article.

10

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1.

Padmanabhan B, Scharlock M, Tong KI, Nakamura Y, Kang MI, Kobayashi A, Matsumoto T, Tanaka A, Yamamoto M, Yokoyama S. Padmanabhan B, et al. Among authors: kobayashi a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt 1):153-5. doi: 10.1107/S1744309104032506. Epub 2004 Dec 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16508120 Free PMC article.

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