Wells TN - Search Results

1

ATP-citrate lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-beta-lactam containing analogues of citric acid as potential tight-binding inhibitors.

Dolle RE, McNair D, Hughes MJ, Kruse LI, Eggelston D, Saxty BA, Wells TN, Groot PH. Dolle RE, et al. Among authors: wells tn. J Med Chem. 1992 Dec 25;35(26):4875-84. doi: 10.1021/jm00104a014. J Med Chem. 1992. PMID: 1479587

2

Cloning and expression of a human ATP-citrate lyase cDNA.

Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS. Elshourbagy NA, et al. Among authors: wells tn. Eur J Biochem. 1992 Mar 1;204(2):491-9. doi: 10.1111/j.1432-1033.1992.tb16659.x. Eur J Biochem. 1992. PMID: 1371749 Free article.

3

Redox control of catalysis in ATP-citrate lysate from rat liver.

Wells TN, Saxty BA. Wells TN, et al. Eur J Biochem. 1992 Feb 15;204(1):249-55. doi: 10.1111/j.1432-1033.1992.tb16631.x. Eur J Biochem. 1992. PMID: 1740136 Free article.

4

Synthesis and evaluation of (+) and (-)-2,2-difluorocitrate as inhibitors of rat-liver ATP-citrate lyase and porcine-heart aconitase.

Saxty BA, Novelli R, Dolle RE, Kruse LI, Reid DG, Camilleri P, Wells TN. Saxty BA, et al. Among authors: wells tn. Eur J Biochem. 1991 Dec 18;202(3):889-96. doi: 10.1111/j.1432-1033.1991.tb16448.x. Eur J Biochem. 1991. PMID: 1765100 Free article.

5

Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase.

Dolle RE, Gribble A, Wilkes T, Kruse LI, Eggleston D, Saxty BA, Wells TN, Groot PH. Dolle RE, et al. Among authors: wells tn. J Med Chem. 1995 Feb 3;38(3):537-43. doi: 10.1021/jm00003a016. J Med Chem. 1995. PMID: 7853346

6

Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age.

Elshourbagy NA, Near JC, Kmetz PJ, Sathe GM, Southan C, Strickler JE, Gross M, Young JF, Wells TN, Groot PH. Elshourbagy NA, et al. Among authors: wells tn. J Biol Chem. 1990 Jan 25;265(3):1430-5. J Biol Chem. 1990. PMID: 2295639 Free article.

7

Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing.

Wang N, Southan C, DeWolf WE Jr, Wells TN, Kruse LI, Leatherbarrow RJ. Wang N, et al. Among authors: wells tn. Biochemistry. 1990 Jul 10;29(27):6466-74. doi: 10.1021/bi00479a019. Biochemistry. 1990. PMID: 2207088

8

ATP-citrate lyase from rat liver. Characterisation of the citryl-enzyme complexes.

Wells TN. Wells TN. Eur J Biochem. 1991 Jul 1;199(1):163-8. doi: 10.1111/j.1432-1033.1991.tb16105.x. Eur J Biochem. 1991. PMID: 1648484 Free article.

9

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development.

Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB. Le TG, et al. J Med Chem. 2019 Jan 24;62(2):1036-1053. doi: 10.1021/acs.jmedchem.8b01789. Epub 2019 Jan 7. J Med Chem. 2019. PMID: 30571110

10

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.

Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB. Le TG, et al. J Med Chem. 2019 Apr 11;62(7):3367-3380. doi: 10.1021/acs.jmedchem.8b01790. Epub 2019 Mar 28. J Med Chem. 2019. PMID: 30875218

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