O'Shea PD - Search Results

1

Oxazolidine ring opening and isomerization to (E)-imines. Asymmetric synthesis of aryl-alpha-fluoroalkyl amino alcohols.

Gosselin F, Roy A, O'Shea PD, Chen CY, Volante RP. Gosselin F, et al. Org Lett. 2004 Feb 19;6(4):641-4. doi: 10.1021/ol036486g. Org Lett. 2004. PMID: 14961643

2

Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives.

Bolshan Y, Chen CY, Chilenski JR, Gosselin F, Mathre DJ, O'Shea PD, Roy A, Tillyer RD. Bolshan Y, et al. Org Lett. 2004 Jan 8;6(1):111-4. doi: 10.1021/ol0361655. Org Lett. 2004. PMID: 14703363

3

Unprecedented catalytic asymmetric reduction of N-H imines.

Gosselin F, O'Shea PD, Roy S, Reamer RA, Chen CY, Volante RP. Gosselin F, et al. Org Lett. 2005 Jan 20;7(2):355-8. doi: 10.1021/ol047431x. Org Lett. 2005. PMID: 15646996

4

Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor.

Roy A, Gosselin F, O'Shea PD, Chen CY. Roy A, et al. J Org Chem. 2006 May 26;71(11):4320-3. doi: 10.1021/jo052430j. J Org Chem. 2006. PMID: 16709080

5

A practical enantioselective synthesis of odanacatib, a potent Cathepsin K inhibitor, via triflate displacement of an alpha-trifluoromethylbenzyl triflate.

O'Shea PD, Chen CY, Gauvreau D, Gosselin F, Hughes G, Nadeau C, Volante RP. O'Shea PD, et al. J Org Chem. 2009 Feb 20;74(4):1605-10. doi: 10.1021/jo8020314. J Org Chem. 2009. PMID: 19140725

6

Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.

O'Shea PD, Chen CY, Chen W, Dagneau P, Frey LF, Grabowski EJ, Marcantonio KM, Reamer RA, Tan L, Tillyer RD, Roy A, Wang X, Zhao D. O'Shea PD, et al. J Org Chem. 2005 Apr 15;70(8):3021-30. doi: 10.1021/jo048156v. J Org Chem. 2005. PMID: 15822960

7

Superior reactivity of thiosemicarbazides in the synthesis of 2-amino-1,3,4-oxadiazoles.

Dolman SJ, Gosselin F, O'Shea PD, Davies IW. Dolman SJ, et al. J Org Chem. 2006 Dec 8;71(25):9548-51. doi: 10.1021/jo0618730. J Org Chem. 2006. PMID: 17137395

8

A practical synthesis of alpha-aryl methyl ketones via a transition-metal-free Meerwein arylation.

Molinaro C, Mowat J, Gosselin F, O'Shea PD, Marcoux JF, Angelaud R, Davies IW. Molinaro C, et al. J Org Chem. 2007 Mar 2;72(5):1856-8. doi: 10.1021/jo062483g. Epub 2007 Jan 31. J Org Chem. 2007. PMID: 17263583

9

Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide.

O'Shea PD, Gauvreau D, Gosselin F, Hughes G, Nadeau C, Roy A, Shultz CS. O'Shea PD, et al. J Org Chem. 2009 Jun 19;74(12):4547-53. doi: 10.1021/jo802772d. J Org Chem. 2009. PMID: 19456171

10

A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285.

Gosselin F, Lau S, Nadeau C, Trinh T, O'Shea PD, Davies IW. Gosselin F, et al. Among authors: o shea pd. J Org Chem. 2009 Oct 16;74(20):7790-7. doi: 10.1021/jo901798d. J Org Chem. 2009. PMID: 19777997

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