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96 results

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Page 1
Novel inhibitors of fatty acid oxidation as potential metabolic modulators.
Elzein E, Shenk K, Ibrahim P, Marquart T, Kerwar S, Meyer S, Ahmed H, Zeng D, Chu N, Soohoo D, Wong S, Leung K, Zablocki J. Elzein E, et al. Among authors: ibrahim p. Bioorg Med Chem Lett. 2004 Feb 23;14(4):973-7. doi: 10.1016/j.bmcl.2003.11.065. Bioorg Med Chem Lett. 2004. PMID: 15013004
Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.
Morrison CF, Elzein E, Jiang B, Ibrahim PN, Marquart T, Palle V, Shenk KD, Varkhedkar V, Maa T, Wu L, Wu Y, Zeng D, Fong I, Lustig D, Leung K, Zablocki JA. Morrison CF, et al. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3793-7. doi: 10.1016/j.bmcl.2004.04.096. Bioorg Med Chem Lett. 2004. PMID: 15203164
Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF).
Palle VP, Varkhedkar V, Ibrahim P, Ahmed H, Li Z, Gao Z, Ozeck M, Wu Y, Zeng D, Wu L, Leung K, Chu N, Zablocki JA. Palle VP, et al. Among authors: ibrahim p. Bioorg Med Chem Lett. 2004 Jan 19;14(2):535-9. doi: 10.1016/j.bmcl.2003.09.094. Bioorg Med Chem Lett. 2004. PMID: 14698198
CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.
Elzein E, Ibrahim P, Koltun DO, Rehder K, Shenk KD, Marquart TA, Jiang B, Li X, Natero R, Li Y, Nguyen M, Kerwar S, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Zeng D, Leung K, Zablocki JA. Elzein E, et al. Among authors: ibrahim p. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6017-21. doi: 10.1016/j.bmcl.2004.09.077. Bioorg Med Chem Lett. 2004. PMID: 15546720
Phosphodiesterase-4 as a potential drug target.
Zhang KY, Ibrahim PN, Gillette S, Bollag G. Zhang KY, et al. Expert Opin Ther Targets. 2005 Dec;9(6):1283-305. doi: 10.1517/14728222.9.6.1283. Expert Opin Ther Targets. 2005. PMID: 16300476 Review.
Structural basis for the activity of drugs that inhibit phosphodiesterases.
Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY. Card GL, et al. Among authors: ibrahim pn. Structure. 2004 Dec;12(12):2233-47. doi: 10.1016/j.str.2004.10.004. Structure. 2004. PMID: 15576036 Free article.
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K. Bollag G, et al. Among authors: ibrahim pn. Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454. Nature. 2010. PMID: 20823850 Free PMC article. Clinical Trial.
Vemurafenib: the first drug approved for BRAF-mutant cancer.
Bollag G, Tsai J, Zhang J, Zhang C, Ibrahim P, Nolop K, Hirth P. Bollag G, et al. Among authors: ibrahim p. Nat Rev Drug Discov. 2012 Nov;11(11):873-86. doi: 10.1038/nrd3847. Epub 2012 Oct 12. Nat Rev Drug Discov. 2012. PMID: 23060265 Review.
96 results