Kan HY - Search Results

1

Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.

Zannis VI, Chroni A, Kypreos KE, Kan HY, Cesar TB, Zanni EE, Kardassis D. Zannis VI, et al. Among authors: kan hy. Curr Opin Lipidol. 2004 Apr;15(2):151-66. doi: 10.1097/00041433-200404000-00008. Curr Opin Lipidol. 2004. PMID: 15017358 Review.

2

Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.

Chroni A, Kan HY, Kypreos KE, Gorshkova IN, Shkodrani A, Zannis VI. Chroni A, et al. Among authors: kan hy. Biochemistry. 2004 Aug 17;43(32):10442-57. doi: 10.1021/bi049782p. Biochemistry. 2004. PMID: 15301543

3

Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice.

Chroni A, Kan HY, Shkodrani A, Liu T, Zannis VI. Chroni A, et al. Among authors: kan hy. Biochemistry. 2005 Mar 15;44(10):4108-17. doi: 10.1021/bi047998l. Biochemistry. 2005. PMID: 15751988

4

Transcriptional regulatory mechanisms of the human apolipoprotein genes in vitro and in vivo.

Zannis VI, Kan HY, Kritis A, Zanni EE, Kardassis D. Zannis VI, et al. Among authors: kan hy. Curr Opin Lipidol. 2001 Apr;12(2):181-207. doi: 10.1097/00041433-200104000-00012. Curr Opin Lipidol. 2001. PMID: 11264990 Review.

5

The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport.

Liu T, Krieger M, Kan HY, Zannis VI. Liu T, et al. Among authors: kan hy. J Biol Chem. 2002 Jun 14;277(24):21576-84. doi: 10.1074/jbc.M112103200. Epub 2002 Mar 6. J Biol Chem. 2002. PMID: 11882653 Free article.

6

Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells.

Georgopoulos S, McKee A, Kan HY, Zannis VI. Georgopoulos S, et al. Among authors: kan hy. Biochemistry. 2002 Jul 30;41(30):9293-301. doi: 10.1021/bi015971l. Biochemistry. 2002. PMID: 12135350

7

The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.

Chroni A, Liu T, Gorshkova I, Kan HY, Uehara Y, Von Eckardstein A, Zannis VI. Chroni A, et al. Among authors: kan hy. J Biol Chem. 2003 Feb 28;278(9):6719-30. doi: 10.1074/jbc.M205232200. Epub 2002 Dec 17. J Biol Chem. 2003. PMID: 12488454 Free article.

8

Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy.

Zannis VI, Liu T, Zanni M, Kan HY, Kardassis D. Zannis VI, et al. Among authors: kan hy. Clin Chem Lab Med. 2003 Apr;41(4):411-24. doi: 10.1515/CCLM.2003.064. Clin Chem Lab Med. 2003. PMID: 12747582

9

Contribution of the hormone-response elements of the proximal ApoA-I promoter, ApoCIII enhancer, and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic mice.

Kan HY, Georgopoulos S, Zanni M, Shkodrani A, Tzatsos A, Xie HX, Zannis VI. Kan HY, et al. Biochemistry. 2004 May 4;43(17):5084-93. doi: 10.1021/bi035764g. Biochemistry. 2004. PMID: 15109267

10

Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.

Chroni A, Duka A, Kan HY, Liu T, Zannis VI. Chroni A, et al. Among authors: kan hy. Biochemistry. 2005 Nov 1;44(43):14353-66. doi: 10.1021/bi050962o. Biochemistry. 2005. PMID: 16245952

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