Clader JW - Search Results

1

Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.

Palani A, Dugar S, Clader JW, Greenlee WJ, Ruperto V, Duffy RA, Lachowicz JE. Palani A, et al. Among authors: clader jw. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1791-4. doi: 10.1016/j.bmcl.2004.01.033. Bioorg Med Chem Lett. 2004. PMID: 15026073

2

Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Hu Z, Greenlee WJ, Clader J, Boyle CD, Kaminski JJ, Billard W, Binch H 3rd, Crosby G, Ruperto V, Duffy RA, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Lachowicz JE. Wang Y, et al. J Med Chem. 2002 Dec 5;45(25):5415-8. doi: 10.1021/jm0255163. J Med Chem. 2002. PMID: 12459007

3

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Sasikumar TK, Burnett DA, Asberom T, Wu WL, Bennett C, Cole D, Xu R, Greenlee WJ, Clader J, Zhang L, Hyde L. Sasikumar TK, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3645-8. doi: 10.1016/j.bmcl.2010.04.103. Epub 2010 Apr 28. Bioorg Med Chem Lett. 2010. PMID: 20471254

4

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.

Wu WL, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee WJ, Josien H, McBriar M, Rajagopalan M, Vicarel M, Xu R, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Wu WL, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):844-9. doi: 10.1016/j.bmcl.2012.11.047. Epub 2012 Nov 24. Bioorg Med Chem Lett. 2013. PMID: 23265892

5

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.

Palani A, Shapiro S, Josien H, Bara T, Clader JW, Greenlee WJ, Cox K, Strizki JM, Baroudy BM. Palani A, et al. Among authors: clader jw. J Med Chem. 2002 Jul 4;45(14):3143-60. doi: 10.1021/jm0200815. J Med Chem. 2002. PMID: 12086500

6

Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist.

Palani A, Shapiro S, Clader JW, Greenlee WJ, Blythin D, Cox K, Wagner NE, Strizki J, Baroudy BM, Dan N. Palani A, et al. Among authors: clader jw. Bioorg Med Chem Lett. 2003 Feb 24;13(4):705-8. doi: 10.1016/s0960-894x(02)01062-4. Bioorg Med Chem Lett. 2003. PMID: 12639563

7

Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.

Palani A, Shapiro S, Clader JW, Greenlee WJ, Vice S, McCombie S, Cox K, Strizki J, Baroudy BM. Palani A, et al. Among authors: clader jw. Bioorg Med Chem Lett. 2003 Feb 24;13(4):709-12. doi: 10.1016/s0960-894x(02)01063-6. Bioorg Med Chem Lett. 2003. PMID: 12639564

8

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.

Clader JW, Billard W, Binch H 3rd, Chen LY, Crosby G Jr, Duffy RA, Ford J, Kozlowski JA, Lachowicz JE, Li S, Liu C, McCombie SW, Vice S, Zhou G, Greenlee WJ. Clader JW, et al. Bioorg Med Chem. 2004 Jan 15;12(2):319-26. doi: 10.1016/j.bmc.2003.11.005. Bioorg Med Chem. 2004. PMID: 14723952

9

SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

Pissarnitski DA, Asberom T, Boyle CD, Chackalamannil S, Chintala M, Clader JW, Greenlee WJ, Hu Y, Kurowski S, Myers J, Palamanda J, Stamford AW, Vemulapalli S, Wang Y, Wang P, Wu P, Xu R. Pissarnitski DA, et al. Among authors: clader jw. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1291-4. doi: 10.1016/j.bmcl.2003.12.027. Bioorg Med Chem Lett. 2004. PMID: 14980684

10

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B. McBriar MD, et al. Among authors: clader jw. J Med Chem. 2005 Apr 7;48(7):2274-7. doi: 10.1021/jm049035q. J Med Chem. 2005. PMID: 15801820

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