Valentin JP - Search Results

1

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes.

Abi-Gerges N, Philp K, Pollard C, Wakefield I, Hammond TG, Valentin JP. Abi-Gerges N, et al. Among authors: valentin jp. Fundam Clin Pharmacol. 2004 Apr;18(2):139-51. doi: 10.1111/j.1472-8206.2004.00230.x. Fundam Clin Pharmacol. 2004. PMID: 15066127 Review.

2

The application of in vitro methods to safety pharmacology.

Wakefield ID, Pollard C, Redfern WS, Hammond TG, Valentin JP. Wakefield ID, et al. Among authors: valentin jp. Fundam Clin Pharmacol. 2002 Jun;16(3):209-18. doi: 10.1046/j.1472-8206.2002.00099.x. Fundam Clin Pharmacol. 2002. PMID: 12165068 Review.

3

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

Abi-Gerges N, Small BG, Lawrence CL, Hammond TG, Valentin JP, Pollard CE. Abi-Gerges N, et al. Among authors: valentin jp. Br J Pharmacol. 2004 Aug;142(8):1255-64. doi: 10.1038/sj.bjp.0705880. Epub 2004 Jul 20. Br J Pharmacol. 2004. PMID: 15265803 Free PMC article.

4

Nonclinical proarrhythmia models: predicting Torsades de Pointes.

Lawrence CL, Pollard CE, Hammond TG, Valentin JP. Lawrence CL, et al. Among authors: valentin jp. J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):46-59. doi: 10.1016/j.vascn.2005.04.011. J Pharmacol Toxicol Methods. 2005. PMID: 15975832 Review.

5

Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, beta-adrenoceptor stimulation, pacing rate and gender.

Abi-Gerges N, Small BG, Lawrence CL, Hammond TG, Valentin JP, Pollard CE. Abi-Gerges N, et al. Among authors: valentin jp. Br J Pharmacol. 2006 Mar;147(6):653-60. doi: 10.1038/sj.bjp.0706491. Br J Pharmacol. 2006. PMID: 16314855 Free PMC article.

6

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential.

Abi-Gerges N, Valentin JP, Pollard CE. Abi-Gerges N, et al. Among authors: valentin jp. Br J Pharmacol. 2010 Jan;159(1):77-92. doi: 10.1111/j.1476-5381.2009.00338.x. Epub 2009 Aug 6. Br J Pharmacol. 2010. PMID: 19663882 Free PMC article.

7

Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines.

Valentin JP, Pollard C, Lainée P, Hammond T. Valentin JP, et al. Br J Pharmacol. 2010 Jan;159(1):25-33. doi: 10.1111/j.1476-5381.2009.00530.x. Br J Pharmacol. 2010. PMID: 20141518 Free PMC article. Review.

8

Safety pharmacology--a progressive approach.

Redfern WS, Wakefield ID, Prior H, Pollard CE, Hammond TG, Valentin JP. Redfern WS, et al. Among authors: valentin jp. Fundam Clin Pharmacol. 2002 Jun;16(3):161-73. doi: 10.1046/j.1472-8206.2002.00098.x. Fundam Clin Pharmacol. 2002. PMID: 12165064

9

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.

Valentin JP, Hoffmann P, De Clerck F, Hammond TG, Hondeghem L. Valentin JP, et al. J Pharmacol Toxicol Methods. 2004 May-Jun;49(3):171-81. doi: 10.1016/j.vascn.2004.03.008. J Pharmacol Toxicol Methods. 2004. PMID: 15172013 Review.

10

Safety and secondary pharmacology: successes, threats, challenges and opportunities.

Valentin JP, Hammond T. Valentin JP, et al. J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):77-87. doi: 10.1016/j.vascn.2008.05.007. Epub 2008 Jun 3. J Pharmacol Toxicol Methods. 2008. PMID: 18586111 Review.

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