Gadek TR - Search Results

1

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR. Burdick DJ, et al. Among authors: gadek tr. Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9. doi: 10.1016/j.bmcl.2004.02.046. Bioorg Med Chem Lett. 2004. PMID: 15080978

2

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR. Burdick DJ, et al. Among authors: gadek tr. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8. doi: 10.1016/s0960-894x(03)00084-2. Bioorg Med Chem Lett. 2003. PMID: 12643901

3

Structure-activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors.

Ockey DA, Dotson JL, Struble ME, Stults JT, Bourell JH, Clark KR, Gadek TR. Ockey DA, et al. Among authors: gadek tr. Bioorg Med Chem. 2004 Jan 2;12(1):37-44. doi: 10.1016/j.bmc.2003.10.053. Bioorg Med Chem. 2004. PMID: 14697768

4

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

Keating SM, Clark KR, Stefanich LD, Arellano F, Edwards CP, Bodary SC, Spencer SA, Gadek TR, Marsters JC Jr, Beresini MH. Keating SM, et al. Among authors: gadek tr. Protein Sci. 2006 Feb;15(2):290-303. doi: 10.1110/ps.051583406. Epub 2005 Dec 29. Protein Sci. 2006. PMID: 16384997 Free PMC article.

5

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Gadek TR, et al. Science. 2002 Feb 8;295(5557):1086-9. doi: 10.1126/science.295.5557.1086. Science. 2002. PMID: 11834839

6

Discovery of small molecule leads in a biotechnology datastream.

Gadek TR, McDowell RS. Gadek TR, et al. Drug Discov Today. 2003 Jun 15;8(12):545-50. doi: 10.1016/s1359-6446(03)02735-1. Drug Discov Today. 2003. PMID: 12821302 Review.

7

Cyclic RGD peptide analogues as antiplatelet antithrombotics.

Barker PL, Bullens S, Bunting S, Burdick DJ, Chan KS, Deisher T, Eigenbrot C, Gadek TR, Gantzos R, Lipari MT, et al. Barker PL, et al. Among authors: gadek tr. J Med Chem. 1992 May 29;35(11):2040-8. doi: 10.1021/jm00089a014. J Med Chem. 1992. PMID: 1597855

8

Discovery of novel PTP1b inhibitors.

Ockey DA, Gadek TR. Ockey DA, et al. Among authors: gadek tr. Bioorg Med Chem Lett. 2004 Jan 19;14(2):389-91. doi: 10.1016/j.bmcl.2003.10.058. Bioorg Med Chem Lett. 2004. PMID: 14698165

9

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.

Khojasteh SC, Leipold DD, Lai F, La H, Baumgardner MJ, Desino KE, Gudmundsson OS, Bloedow DC, Bodary SC, Reynolds ME, Gadek TR, Kenkare-Mitra S. Khojasteh SC, et al. Among authors: gadek tr. Xenobiotica. 2008 Mar;38(3):340-52. doi: 10.1080/00498250701813248. Xenobiotica. 2008. PMID: 18274961

10

Structural determinants of calcium signaling by RGD peptides in rat osteoclasts: integrin-dependent and -independent actions.

Shankar G, Gadek TR, Burdick DJ, Davison I, Mason WT, Horton MA. Shankar G, et al. Among authors: gadek tr. Exp Cell Res. 1995 Aug;219(2):364-71. doi: 10.1006/excr.1995.1240. Exp Cell Res. 1995. PMID: 7543851

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