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Novel dual acting molecules possessing 5-lipoxygenase enzyme inhibition and histamine H(1) receptor antagonist properties.
Scannell RT, Arrington MP, Bayless L, Cai X, Eckman JB, Eckert M, Ene DG, Ellis JL, Hussoin S, Latham GM, Lewis TA, Libertine L, Nicolas J, Selig WM, Schwartz CE, Wels BF, Wypij DM, Young MA, Zou D. Scannell RT, et al. Among authors: lewis ta. Inflamm Res. 2004 Mar;53 Suppl 1:S33-4. doi: 10.1007/s00011-003-0315-4. Epub 2004 Mar 5. Inflamm Res. 2004. PMID: 15054606 No abstract available.
Discovery of new C3aR ligands. Part 1: arginine derivatives.
Denonne F, Binet S, Burton M, Collart P, Dipesa A, Ganguly T, Giannaras A, Kumar S, Lewis T, Maounis F, Nicolas JM, Mansley T, Pasau P, Preda D, Stebbins K, Volosov A, Zou D. Denonne F, et al. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3258-61. doi: 10.1016/j.bmcl.2007.04.022. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17467987
Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12.
Lewis TA, Ellermann M, Kopitz C, Lange M, de Waal L, Wu X, Tersteegen A, Denner K, Lienau P, Kaulfuss S, Goldoni S, Meyerson M, Greulich H, Gradl SN. Lewis TA, et al. ACS Med Chem Lett. 2024 Sep 10;15(10):1662-1667. doi: 10.1021/acsmedchemlett.4c00336. eCollection 2024 Oct 10. ACS Med Chem Lett. 2024. PMID: 39411532
Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression.
Aquilanti E, Goldoni S, Baker A, Kotynkova K, Andersen S, Bozinov V, Gao GF, Cherniack AD, Lange M, Lesche R, Kopitz C, Lienau P, Lewis TA, Garrido M, Gradl S, Seidel H, Tseng YY, Ligon KL, Wen PY, Meyerson M, Greulich H. Aquilanti E, et al. Among authors: lewis ta. Neurooncol Adv. 2024 Jul 1;6(1):vdae115. doi: 10.1093/noajnl/vdae115. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 39166256 Free PMC article.
110 results