Timmerman H - Search Results

1

Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats.

Huang YW, Hu WW, Chen Z, Zhang LS, Shen HQ, Timmerman H, Leurs R, Yanai K. Huang YW, et al. Among authors: timmerman h. Behav Brain Res. 2004 May 5;151(1-2):287-93. doi: 10.1016/j.bbr.2003.09.002. Behav Brain Res. 2004. PMID: 15084444

2

Improgan antinociception does not require neuronal histamine or histamine receptors.

Izadi Mobarakeh J, Nalwalk JW, Watanabe T, Sakurada S, Hoffman M, Leurs R, Timmerman H, Silos-Santiago I, Yanai K, Hough LB. Izadi Mobarakeh J, et al. Among authors: timmerman h. Brain Res. 2003 Jun 6;974(1-2):146-52. doi: 10.1016/s0006-8993(03)02572-1. Brain Res. 2003. PMID: 12742632

3

Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats.

Zhang L, Chen Z, Ren K, Leurs R, Chen J, Zhang W, Ye B, Wei E, Timmerman H. Zhang L, et al. Among authors: timmerman h. Eur J Pharmacol. 2003 Dec 15;482(1-3):169-75. doi: 10.1016/j.ejphar.2003.09.066. Eur J Pharmacol. 2003. PMID: 14660019

4

Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor/cyclic AMP/protein kinase A and H receptor/GABA release pathways.

Dai H, Zhang Z, Zhu Y, Shen Y, Hu W, Huang Y, Luo J, Timmerman H, Leurs R, Chen Z. Dai H, et al. Among authors: timmerman h. J Neurochem. 2006 Mar;96(5):1390-400. doi: 10.1111/j.1471-4159.2005.03633.x. J Neurochem. 2006. PMID: 16478529 Free article.

5

The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.

Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. Dai H, et al. Among authors: timmerman h. Eur J Pharmacol. 2007 Jun 1;563(1-3):117-23. doi: 10.1016/j.ejphar.2007.01.069. Epub 2007 Feb 8. Eur J Pharmacol. 2007. PMID: 17350613

6

The histamine H3 receptor: from gene cloning to H3 receptor drugs.

Leurs R, Bakker RA, Timmerman H, de Esch IJ. Leurs R, et al. Among authors: timmerman h. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. doi: 10.1038/nrd1631. Nat Rev Drug Discov. 2005. PMID: 15665857 Review.

7

N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist.

Kitbunnadaj R, Hashimoto T, Poli E, Zuiderveld OP, Menozzi A, Hidaka R, de Esch IJ, Bakker RA, Menge WM, Yamatodani A, Coruzzi G, Timmerman H, Leurs R. Kitbunnadaj R, et al. Among authors: timmerman h. J Med Chem. 2005 Mar 24;48(6):2100-7. doi: 10.1021/jm049475h. J Med Chem. 2005. PMID: 15771452

8

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function.

Govoni M, Lim HD, El-Atmioui D, Menge WM, Timmerman H, Bakker RA, Leurs R, De Esch IJ. Govoni M, et al. Among authors: timmerman h. J Med Chem. 2006 Apr 20;49(8):2549-57. doi: 10.1021/jm0504353. J Med Chem. 2006. PMID: 16610798

9

Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.

Kitbunnadaj R, Zuiderveld OP, De Esch IJ, Vollinga RC, Bakker R, Lutz M, Spek AL, Cavoy E, Deltent MF, Menge WM, Timmerman H, Leurs R. Kitbunnadaj R, et al. Among authors: timmerman h. J Med Chem. 2003 Dec 4;46(25):5445-57. doi: 10.1021/jm030905y. J Med Chem. 2003. PMID: 14640553

10

Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.

Kitbunnadaj R, Zuiderveld OP, Christophe B, Hulscher S, Menge WM, Gelens E, Snip E, Bakker RA, Celanire S, Gillard M, Talaga P, Timmerman H, Leurs R. Kitbunnadaj R, et al. Among authors: timmerman h. J Med Chem. 2004 May 6;47(10):2414-7. doi: 10.1021/jm049932u. J Med Chem. 2004. PMID: 15115383

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