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Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.
Kavanagh D, McGlasson S, Jury A, Williams J, Scolding N, Bellamy C, Gunther C, Ritchie D, Gale DP, Kanwar YS, Challis R, Buist H, Overell J, Weller B, Flossmann O, Blunden M, Meyer EP, Krucker T, Evans SJ, Campbell IL, Jackson AP, Chandran S, Hunt DP. Kavanagh D, et al. Among authors: campbell il. Blood. 2016 Dec 15;128(24):2824-2833. doi: 10.1182/blood-2016-05-715987. Epub 2016 Sep 23. Blood. 2016. PMID: 27663672 Free PMC article.
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies.
Viengkhou B, Hayashida E, McGlasson S, Emelianova K, Forbes D, Wiseman S, Wardlaw J, Verdillo R, Irani SR, Duffy D, Piehl F, Loo L, Pagenstecher A, Neely GG, Crow YJ, Campbell IL, Hunt DPJ, Hofer MJ. Viengkhou B, et al. Among authors: campbell il. Immunity. 2024 Jul 9;57(7):1696-1709.e10. doi: 10.1016/j.immuni.2024.05.017. Epub 2024 Jun 14. Immunity. 2024. PMID: 38878770 Free PMC article.
Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia.
Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Campbell NV, et al. Among authors: campbell il. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L58-L68. doi: 10.1152/ajplung.00104.2022. Epub 2022 May 24. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35608266 Free PMC article.
The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes.
West PK, McCorkindale AN, Guennewig B, Ashhurst TM, Viengkhou B, Hayashida E, Jung SR, Butovsky O, Campbell IL, Hofer MJ. West PK, et al. Among authors: campbell il. J Neuroinflammation. 2022 Apr 16;19(1):96. doi: 10.1186/s12974-022-02441-x. J Neuroinflammation. 2022. PMID: 35429976 Free PMC article.
252 results