Gullen EA - Search Results

1

Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.

Dutschman GE, Grill SP, Gullen EA, Haraguchi K, Takeda S, Tanaka H, Baba M, Cheng YC. Dutschman GE, et al. Among authors: gullen ea. Antimicrob Agents Chemother. 2004 May;48(5):1640-6. doi: 10.1128/AAC.48.5.1640-1646.2004. Antimicrob Agents Chemother. 2004. PMID: 15105115 Free PMC article.

2

A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.

Cheng Y, Tsou LK, Cai J, Aya T, Dutschman GE, Gullen EA, Grill SP, Chen AP, Lindenbach BD, Hamilton AD, Cheng YC. Cheng Y, et al. Among authors: gullen ea. Antimicrob Agents Chemother. 2010 Jan;54(1):197-206. doi: 10.1128/AAC.01206-09. Epub 2009 Nov 9. Antimicrob Agents Chemother. 2010. PMID: 19901090 Free PMC article.

3

Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.

Ray AS, Hernandez-Santiago BI, Mathew JS, Murakami E, Bozeman C, Xie MY, Dutschman GE, Gullen E, Yang Z, Hurwitz S, Cheng YC, Chu CK, McClure H, Schinazi RF, Anderson KS. Ray AS, et al. Antimicrob Agents Chemother. 2005 May;49(5):1994-2001. doi: 10.1128/AAC.49.5.1994-2001.2005. Antimicrob Agents Chemother. 2005. PMID: 15855524 Free PMC article.

4

Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro.

Dutschman GE, Bridges EG, Liu SH, Gullen E, Guo X, Kukhanova M, Cheng YC. Dutschman GE, et al. Antimicrob Agents Chemother. 1998 Jul;42(7):1799-804. doi: 10.1128/AAC.42.7.1799. Antimicrob Agents Chemother. 1998. PMID: 9661024 Free PMC article.

5

Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus.

Bridges EG, Dutschman GE, Gullen EA, Cheng YC. Bridges EG, et al. Among authors: gullen ea. Biochem Pharmacol. 1996 Mar 22;51(6):731-6. doi: 10.1016/0006-2952(96)00056-1. Biochem Pharmacol. 1996. PMID: 8602867 Free article.

6

Metabolism and mode of inhibition of varicella-zoster virus by L-beta-5-bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil is dependent on viral thymidine kinase.

Li L, Dutschman GE, Gullen EA, Tsujii E, Grill SP, Choi Y, Chu CK, Cheng YC. Li L, et al. Among authors: gullen ea. Mol Pharmacol. 2000 Nov;58(5):1109-14. doi: 10.1124/mol.58.5.1109. Mol Pharmacol. 2000. PMID: 11040060

7

Novel role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the activation of L-nucleoside analogs, a new class of anticancer and antiviral agents.

Krishnan P, Gullen EA, Lam W, Dutschman GE, Grill SP, Cheng YC. Krishnan P, et al. Among authors: gullen ea. J Biol Chem. 2003 Sep 19;278(38):36726-32. doi: 10.1074/jbc.M307052200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12869554 Free article.

8

Synthesis and antiviral activity of helioxanthin analogues.

Yeo H, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Yeo H, et al. Among authors: gullen ea. J Med Chem. 2005 Jan 27;48(2):534-46. doi: 10.1021/jm034265a. J Med Chem. 2005. PMID: 15658867

9

Synthesis and biological evaluation of 2',3'-didehydro-2',3'-dideoxy-9-deazaguanosine, a monophosphate prodrug and two analogues, 2',3'-dideoxy-9-deazaguanosine and 2',3'-didehydro-2',3'-dideoxy-9-deazainosine.

Liu MC, Luo MZ, Mozdziesz DE, Dutschman GE, Gullen EA, Cheng YC, Sartorelli AC. Liu MC, et al. Among authors: gullen ea. Nucleosides Nucleotides Nucleic Acids. 2005;24(2):135-45. doi: 10.1081/NCN-51898. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 15822619

10

Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of the 4'-acetoxy group.

Haraguchi K, Shimada H, Tanaka H, Hamasaki T, Baba M, Gullen EA, Dutschman GE, Cheng YC. Haraguchi K, et al. Among authors: gullen ea. J Med Chem. 2008 Mar 27;51(6):1885-93. doi: 10.1021/jm070824s. Epub 2008 Feb 27. J Med Chem. 2008. PMID: 18311897

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