Haraguchi K - Search Results

1

Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.

Dutschman GE, Grill SP, Gullen EA, Haraguchi K, Takeda S, Tanaka H, Baba M, Cheng YC. Dutschman GE, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2004 May;48(5):1640-6. doi: 10.1128/AAC.48.5.1640-1646.2004. Antimicrob Agents Chemother. 2004. PMID: 15105115 Free PMC article.

2

Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.

Nitanda T, Wang X, Kumamoto H, Haraguchi K, Tanaka H, Cheng YC, Baba M. Nitanda T, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2005 Aug;49(8):3355-60. doi: 10.1128/AAC.49.8.3355-3360.2005. Antimicrob Agents Chemother. 2005. PMID: 16048947 Free PMC article.

3

Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Haraguchi K, et al. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3775-7. doi: 10.1016/j.bmcl.2003.07.009. Bioorg Med Chem Lett. 2003. PMID: 14552777

4

Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine.

Haraguchi K, Itoh Y, Takeda S, Honma Y, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Haraguchi K, et al. Nucleosides Nucleotides Nucleic Acids. 2004;23(4):647-54. doi: 10.1081/NCN-120030721. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15200028

5

Synthesis of (+/-)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T).

Kumamoto H, Haraguchi K, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC, Kato K. Kumamoto H, et al. Among authors: haraguchi k. Nucleosides Nucleotides Nucleic Acids. 2005;24(2):73-83. doi: 10.1081/NCN-51900. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 15822615

6

4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.

Tanaka H, Haraguchi K, Kumamoto H, Baba M, Cheng YC. Tanaka H, et al. Among authors: haraguchi k. Antivir Chem Chemother. 2005;16(4):217-21. doi: 10.1177/095632020501600402. Antivir Chem Chemother. 2005. PMID: 16130520 Free article.

7

A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Sumino M, Tanaka H, Dutschman GE, Cheng YC, Nitanda T, Baba M. Haraguchi K, et al. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):343-7. doi: 10.1081/ncn-200059774. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247949

8

Synthesis and anti-human immunodeficiency virus activity of 4'-branched (+/-)-4'-thiostavudines.

Kumamoto H, Nakai T, Haraguchi K, Nakamura KT, Tanaka H, Baba M, Cheng YC. Kumamoto H, et al. Among authors: haraguchi k. J Med Chem. 2006 Dec 28;49(26):7861-7. doi: 10.1021/jm060980j. J Med Chem. 2006. PMID: 17181169

9

Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of the 4'-acetoxy group.

Haraguchi K, Shimada H, Tanaka H, Hamasaki T, Baba M, Gullen EA, Dutschman GE, Cheng YC. Haraguchi K, et al. J Med Chem. 2008 Mar 27;51(6):1885-93. doi: 10.1021/jm070824s. Epub 2008 Feb 27. J Med Chem. 2008. PMID: 18311897

10

Synthesis of carbocyclic analogues of 4'-ethynyl- and 4'-cyano-d4T.

Kumamoto H, Kato K, Haraguchi K, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Kumamoto H, et al. Among authors: haraguchi k. Nucleic Acids Symp Ser (Oxf). 2004;(48):41-2. doi: 10.1093/nass/48.1.41. Nucleic Acids Symp Ser (Oxf). 2004. PMID: 17150468

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