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Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.
Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG. Chan N, et al. Among authors: lakshman m. Cancer Res. 2010 Oct 15;70(20):8045-54. doi: 10.1158/0008-5472.CAN-10-2352. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924112 Free PMC article.
Endoglin suppresses human prostate cancer metastasis.
Lakshman M, Huang X, Ananthanarayanan V, Jovanovic B, Liu Y, Craft CS, Romero D, Vary CP, Bergan RC. Lakshman M, et al. Clin Exp Metastasis. 2011 Jan;28(1):39-53. doi: 10.1007/s10585-010-9356-6. Epub 2010 Oct 28. Clin Exp Metastasis. 2011. PMID: 20981476 Free PMC article.
Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.
Reyes-Gordillo K, Shah R, Arellanes-Robledo J, Hernández-Nazara Z, Rincón-Sánchez AR, Inagaki Y, Rojkind M, Lakshman MR. Reyes-Gordillo K, et al. Among authors: lakshman mr. Am J Pathol. 2014 May;184(5):1458-67. doi: 10.1016/j.ajpath.2014.01.020. Epub 2014 Mar 15. Am J Pathol. 2014. PMID: 24641900 Free PMC article.
Fibrogenic actions of acetaldehyde are β-catenin dependent but Wingless independent: a critical role of nucleoredoxin and reactive oxygen species in human hepatic stellate cells.
Arellanes-Robledo J, Reyes-Gordillo K, Shah R, Domínguez-Rosales JA, Hernández-Nazara ZH, Ramirez F, Rojkind M, Lakshman MR. Arellanes-Robledo J, et al. Among authors: lakshman mr. Free Radic Biol Med. 2013 Dec;65:1487-1496. doi: 10.1016/j.freeradbiomed.2013.07.017. Epub 2013 Jul 20. Free Radic Biol Med. 2013. PMID: 23880292
TGF-β1 up-regulates the expression of PDGF-β receptor mRNA and induces a delayed PI3K-, AKT-, and p70(S6K) -dependent proliferative response in activated hepatic stellate cells.
Shah R, Reyes-Gordillo K, Arellanes-Robledo J, Lechuga CG, Hernández-Nazara Z, Cotty A, Rojkind M, Lakshman MR. Shah R, et al. Among authors: lakshman mr. Alcohol Clin Exp Res. 2013 Nov;37(11):1838-48. doi: 10.1111/acer.12167. Epub 2013 Jul 29. Alcohol Clin Exp Res. 2013. PMID: 23895226
180 results