de Crombrugghe B - Search Results

1

Interactions between Sox9 and beta-catenin control chondrocyte differentiation.

Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, McCrea PD, de Crombrugghe B. Akiyama H, et al. Among authors: de crombrugghe b. Genes Dev. 2004 May 1;18(9):1072-87. doi: 10.1101/gad.1171104. Genes Dev. 2004. PMID: 15132997 Free PMC article.

2

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B. Akiyama H, et al. Among authors: de crombrugghe b. Genes Dev. 2002 Nov 1;16(21):2813-28. doi: 10.1101/gad.1017802. Genes Dev. 2002. PMID: 12414734 Free PMC article.

3

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest.

Mori-Akiyama Y, Akiyama H, Rowitch DH, de Crombrugghe B. Mori-Akiyama Y, et al. Among authors: de crombrugghe b. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9360-5. doi: 10.1073/pnas.1631288100. Epub 2003 Jul 23. Proc Natl Acad Sci U S A. 2003. PMID: 12878728 Free PMC article.

4

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.

Murakami S, Balmes G, McKinney S, Zhang Z, Givol D, de Crombrugghe B. Murakami S, et al. Among authors: de crombrugghe b. Genes Dev. 2004 Feb 1;18(3):290-305. doi: 10.1101/gad.1179104. Genes Dev. 2004. PMID: 14871928 Free PMC article.

5

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.

Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, de Crombrugghe B. Akiyama H, et al. Among authors: de crombrugghe b. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6502-7. doi: 10.1073/pnas.0401711101. Epub 2004 Apr 19. Proc Natl Acad Sci U S A. 2004. PMID: 15096597 Free PMC article.

6

The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.

Akiyama H, Kamitani T, Yang X, Kandyil R, Bridgewater LC, Fellous M, Mori-Akiyama Y, de Crombrugghe B. Akiyama H, et al. Among authors: de crombrugghe b. Matrix Biol. 2005 Jan;23(8):499-505. doi: 10.1016/j.matbio.2004.10.002. Epub 2004 Dec 8. Matrix Biol. 2005. PMID: 15694126

7

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, Zhang Z, Martin JF, Behringer RR, Nakamura T, de Crombrugghe B. Akiyama H, et al. Among authors: de crombrugghe b. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70. doi: 10.1073/pnas.0504750102. Epub 2005 Oct 3. Proc Natl Acad Sci U S A. 2005. PMID: 16203988 Free PMC article.

8

Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.

Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, Sinha K, McCrea PD, de Crombrugghe B. Zhang C, et al. Among authors: de crombrugghe b. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6936-41. doi: 10.1073/pnas.0710831105. Epub 2008 May 5. Proc Natl Acad Sci U S A. 2008. PMID: 18458345 Free PMC article.

9

Sox9 is required for cartilage formation.

Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. Bi W, et al. Among authors: de crombrugghe b. Nat Genet. 1999 May;22(1):85-9. doi: 10.1038/8792. Nat Genet. 1999. PMID: 10319868

10

Transcriptional mechanisms of chondrocyte differentiation.

de Crombrugghe B, Lefebvre V, Behringer RR, Bi W, Murakami S, Huang W. de Crombrugghe B, et al. Matrix Biol. 2000 Sep;19(5):389-94. doi: 10.1016/s0945-053x(00)00094-9. Matrix Biol. 2000. PMID: 10980415 Review.

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