Wang Y - Search Results

1

Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[b]furan-3a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition.

Watts J, Benn A, Flinn N, Monk T, Ramjee M, Ray P, Wang Y, Quibell M. Watts J, et al. Among authors: wang y. Bioorg Med Chem. 2004 Jun 1;12(11):2903-25. doi: 10.1016/j.bmc.2004.03.042. Bioorg Med Chem. 2004. PMID: 15142551

2

Bicyclic peptidomimetic tetrahydrofuro[3,2-b]pyrrol-3-one and hexahydrofuro[3,2-b]pyridine-3-one based scaffolds: synthesis and cysteinyl proteinase inhibition.

Quibell M, Benn A, Flinn N, Monk T, Ramjee M, Wang Y, Watts J. Quibell M, et al. Among authors: wang y. Bioorg Med Chem. 2004 Nov 1;12(21):5689-710. doi: 10.1016/j.bmc.2004.07.054. Bioorg Med Chem. 2004. PMID: 15465346

3

Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases.

Quibell M, Benn A, Flinn N, Monk T, Ramjee M, Ray P, Wang Y, Watts J. Quibell M, et al. Among authors: wang y. Bioorg Med Chem. 2005 Feb 1;13(3):609-25. doi: 10.1016/j.bmc.2004.10.060. Bioorg Med Chem. 2005. PMID: 15653329

4

cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition.

Wang Y, Benn A, Flinn N, Monk T, Ramjee M, Watts J, Quibell M. Wang Y, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1327-31. doi: 10.1016/j.bmcl.2005.01.022. Bioorg Med Chem Lett. 2005. PMID: 15713380

5

Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery.

Ramjee MK, Flinn NS, Pemberton TP, Quibell M, Wang Y, Watts JP. Ramjee MK, et al. Among authors: wang y. Biochem J. 2006 Oct 1;399(1):47-57. doi: 10.1042/BJ20060422. Biochem J. 2006. PMID: 16776649 Free PMC article.

6

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Macias AT, Williamson DS, Allen N, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, Francis GL, Graham CJ, Howes R, Matassova N, Murray JB, Parsons R, Shaw T, Surgenor AE, Terry L, Wang Y, Wood M, Massey AJ. Macias AT, et al. Among authors: wang y. J Med Chem. 2011 Jun 23;54(12):4034-41. doi: 10.1021/jm101625x. Epub 2011 May 20. J Med Chem. 2011. PMID: 21526763

7

Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.

Williamson DS, Smith GP, Mikkelsen GK, Jensen T, Acheson-Dossang P, Badolo L, Bedford ST, Chell V, Chen IJ, Dokurno P, Hentzer M, Newland S, Ray SC, Shaw T, Surgenor AE, Terry L, Wang Y, Christensen KV. Williamson DS, et al. Among authors: wang y. J Med Chem. 2021 Jul 22;64(14):10312-10332. doi: 10.1021/acs.jmedchem.1c00720. Epub 2021 Jun 29. J Med Chem. 2021. PMID: 34184879 Free article.

8

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

Williamson DS, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, Foloppe N, Francis GL, Graham CJ, Howes R, Macias AT, Murray JB, Parsons R, Shaw T, Surgenor AE, Terry L, Wang Y, Wood M, Massey AJ. Williamson DS, et al. Among authors: wang y. J Med Chem. 2009 Mar 26;52(6):1510-3. doi: 10.1021/jm801627a. J Med Chem. 2009. PMID: 19256508

9

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Brough PA, Baker L, Bedford S, Brown K, Chavda S, Chell V, D'Alessandro J, Davies NG, Davis B, Le Strat L, Macias AT, Maddox D, Mahon PC, Massey AJ, Matassova N, McKenna S, Meissner JW, Moore JD, Murray JB, Northfield CJ, Parry C, Parsons R, Roughley SD, Shaw T, Simmonite H, Stokes S, Surgenor A, Stefaniak E, Robertson A, Wang Y, Webb P, Whitehead N, Wood M. Brough PA, et al. Among authors: wang y. J Med Chem. 2017 Mar 23;60(6):2271-2286. doi: 10.1021/acs.jmedchem.6b01478. Epub 2017 Feb 15. J Med Chem. 2017. PMID: 28199108

10

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

Williamson DS, Smith GP, Acheson-Dossang P, Bedford ST, Chell V, Chen IJ, Daechsel JCA, Daniels Z, David L, Dokurno P, Hentzer M, Herzig MC, Hubbard RE, Moore JD, Murray JB, Newland S, Ray SC, Shaw T, Surgenor AE, Terry L, Thirstrup K, Wang Y, Christensen KV. Williamson DS, et al. Among authors: wang y. J Med Chem. 2017 Nov 9;60(21):8945-8962. doi: 10.1021/acs.jmedchem.7b01186. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29023112 Free article.

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