Tota MR - Search Results

1

Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.

Scapin G, Patel SB, Chung C, Varnerin JP, Edmondson SD, Mastracchio A, Parmee ER, Singh SB, Becker JW, Van der Ploeg LH, Tota MR. Scapin G, et al. Among authors: tota mr. Biochemistry. 2004 May 25;43(20):6091-100. doi: 10.1021/bi049868i. Biochemistry. 2004. PMID: 15147193

2

The role of tryptophan 1072 in human PDE3B inhibitor binding.

Chung C, Varnerin JP, Morin NR, MacNeil DJ, Singh SB, Patel S, Scapin G, Van der Ploeg LH, Tota MR. Chung C, et al. Among authors: tota mr. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1045-50. doi: 10.1016/s0006-291x(03)01299-3. Biochem Biophys Res Commun. 2003. PMID: 12878217

3

Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.

Edmondson SD, Mastracchio A, He J, Chung CC, Forrest MJ, Hofsess S, MacIntyre E, Metzger J, O'Connor N, Patel K, Tong X, Tota MR, Van der Ploeg LH, Varnerin JP, Fisher MH, Wyvratt MJ, Weber AE, Parmee ER. Edmondson SD, et al. Among authors: tota mr. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3983-7. doi: 10.1016/j.bmcl.2003.08.056. Bioorg Med Chem Lett. 2003. PMID: 14592490

4

Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B.

Patel SB, Varnerin JP, Tota MR, Edmondson SD, Parmee ER, Becker JW, Scapin G. Patel SB, et al. Among authors: tota mr. Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):169-71. doi: 10.1107/s0907444903025101. Epub 2003 Dec 18. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14684919

5

Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core.

Varnerin JP, Chung CC, Patel SB, Scapin G, Parmee ER, Morin NR, MacNeil DJ, Cully DF, Van der Ploeg LH, Tota MR. Varnerin JP, et al. Among authors: tota mr. Protein Expr Purif. 2004 Jun;35(2):225-36. doi: 10.1016/j.pep.2004.01.009. Protein Expr Purif. 2004. PMID: 15135397

6

Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.

Tota MR, Smith TS, Mao C, MacNeil T, Mosley RT, Van der Ploeg LH, Fong TM. Tota MR, et al. Biochemistry. 1999 Jan 19;38(3):897-904. doi: 10.1021/bi9815602. Biochemistry. 1999. PMID: 9893984

7

Molecular determinants of ligand binding to the human melanocortin-4 receptor.

Yang YK, Fong TM, Dickinson CJ, Mao C, Li JY, Tota MR, Mosley R, Van Der Ploeg LH, Gantz I. Yang YK, et al. Among authors: tota mr. Biochemistry. 2000 Dec 5;39(48):14900-11. doi: 10.1021/bi001684q. Biochemistry. 2000. PMID: 11101306

8

A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.

Chung CC, Ohwaki K, Schneeweis JE, Stec E, Varnerin JP, Goudreau PN, Chang A, Cassaday J, Yang L, Yamakawa T, Kornienko O, Hodder P, Inglese J, Ferrer M, Strulovici B, Kusunoki J, Tota MR, Takagi T. Chung CC, et al. Among authors: tota mr. Assay Drug Dev Technol. 2008 Jun;6(3):361-74. doi: 10.1089/adt.2007.105. Assay Drug Dev Technol. 2008. PMID: 18452391

9

Localization of leptin binding domain in the leptin receptor.

Fong TM, Huang RR, Tota MR, Mao C, Smith T, Varnerin J, Karpitskiy VV, Krause JE, Van der Ploeg LH. Fong TM, et al. Among authors: tota mr. Mol Pharmacol. 1998 Feb;53(2):234-40. doi: 10.1124/mol.53.2.234. Mol Pharmacol. 1998. PMID: 9463481

10

A rapid, quantitative functional assay for measuring leptin.

Rosenblum CI, Vongs A, Tota MR, Varnerin JP, Frazier E, Cully DF, Morsy MA, Van der Ploeg LH. Rosenblum CI, et al. Among authors: tota mr. Mol Cell Endocrinol. 1998 Aug 25;143(1-2):117-23. doi: 10.1016/s0303-7207(98)00129-4. Mol Cell Endocrinol. 1998. PMID: 9806356

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