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The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways.
Conway EM, Van de Wouwer M, Pollefeyt S, Jurk K, Van Aken H, De Vriese A, Weitz JI, Weiler H, Hellings PW, Schaeffer P, Herbert JM, Collen D, Theilmeier G. Conway EM, et al. J Exp Med. 2002 Sep 2;196(5):565-77. doi: 10.1084/jem.20020077. J Exp Med. 2002. PMID: 12208873 Free PMC article.
Survivin determines cardiac function by controlling total cardiomyocyte number.
Levkau B, Schäfers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, Kawaguchi N, Kirchhof P, Fabritz L, Stypmann J, Stegger L, Flögel U, Schrader J, Fischer JW, Hsieh P, Ou YL, Mehrhof F, Tiemann K, Ghanem A, Matus M, Neumann J, Heusch G, Schmid KW, Conway EM, Baba HA. Levkau B, et al. Among authors: conway em. Circulation. 2008 Mar 25;117(12):1583-93. doi: 10.1161/CIRCULATIONAHA.107.734160. Epub 2008 Mar 10. Circulation. 2008. PMID: 18332262
Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin.
Coremans V, Ahmed T, Balschun D, D'Hooge R, DeVriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch A, Lagace D, Janssens T, Bozzi Y, Caleo M, Conway EM. Coremans V, et al. Among authors: conway em. BMC Neurosci. 2010 Jan 5;11:2. doi: 10.1186/1471-2202-11-2. BMC Neurosci. 2010. PMID: 20051123 Free PMC article.
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.
Brun SN, Markant SL, Esparza LA, Garcia G, Terry D, Huang JM, Pavlyukov MS, Li XN, Grant GA, Crawford JR, Levy ML, Conway EM, Smith LH, Nakano I, Berezov A, Greene MI, Wang Q, Wechsler-Reya RJ. Brun SN, et al. Among authors: conway em. Oncogene. 2015 Jul;34(29):3770-9. doi: 10.1038/onc.2014.304. Epub 2014 Sep 22. Oncogene. 2015. PMID: 25241898 Free PMC article.
155 results