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Page 1
Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents.
Wissner A, Brawner Floyd MB, Rabindran SK, Nilakantan R, Greenberger LM, Shen R, Wang YF, Tsou HR. Wissner A, et al. Among authors: rabindran sk. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2893-7. doi: 10.1016/s0960-894x(02)00598-x. Bioorg Med Chem Lett. 2002. PMID: 12270171
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).
Wissner A, Overbeek E, Reich MF, Floyd MB, Johnson BD, Mamuya N, Rosfjord EC, Discafani C, Davis R, Shi X, Rabindran SK, Gruber BC, Ye F, Hallett WA, Nilakantan R, Shen R, Wang YF, Greenberger LM, Tsou HR. Wissner A, et al. Among authors: rabindran sk. J Med Chem. 2003 Jan 2;46(1):49-63. doi: 10.1021/jm020241c. J Med Chem. 2003. PMID: 12502359
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.
Tsou HR, Overbeek-Klumpers EG, Hallett WA, Reich MF, Floyd MB, Johnson BD, Michalak RS, Nilakantan R, Discafani C, Golas J, Rabindran SK, Shen R, Shi X, Wang YF, Upeslacis J, Wissner A. Tsou HR, et al. Among authors: rabindran sk. J Med Chem. 2005 Feb 24;48(4):1107-31. doi: 10.1021/jm040159c. J Med Chem. 2005. PMID: 15715478
4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.
Zhang N, Wu B, Wissner A, Powell DW, Rabindran SK, Kohler C, Boschelli F. Zhang N, et al. Among authors: rabindran sk. Bioorg Med Chem Lett. 2002 Feb 11;12(3):423-5. doi: 10.1016/s0960-894x(01)00776-4. Bioorg Med Chem Lett. 2002. PMID: 11814812
Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression.
Grillo M, Bott MJ, Khandke N, McGinnis JP, Miranda M, Meyyappan M, Rosfjord EC, Rabindran SK. Grillo M, et al. Among authors: rabindran sk. Breast Cancer Res Treat. 2006 Jan;95(2):185-94. doi: 10.1007/s10549-005-9066-y. Epub 2005 Dec 1. Breast Cancer Res Treat. 2006. PMID: 16319987
Antitumor activity of HER-2 inhibitors.
Rabindran SK. Rabindran SK. Cancer Lett. 2005 Sep 8;227(1):9-23. doi: 10.1016/j.canlet.2004.11.015. Epub 2004 Dec 15. Cancer Lett. 2005. PMID: 16051028 Review.
40 results