Van Delft M - Search Results

1

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9.

Marsden VS, Ekert PG, Van Delft M, Vaux DL, Adams JM, Strasser A. Marsden VS, et al. Among authors: van delft m. J Cell Biol. 2004 Jun 21;165(6):775-80. doi: 10.1083/jcb.200312030. J Cell Biol. 2004. PMID: 15210727 Free PMC article.

2

How the Bcl-2 family of proteins interact to regulate apoptosis.

van Delft MF, Huang DC. van Delft MF, et al. Cell Res. 2006 Feb;16(2):203-13. doi: 10.1038/sj.cr.7310028. Cell Res. 2006. PMID: 16474435 Review.

3

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

Adams JM, Huang DC, Strasser A, Willis S, Chen L, Wei A, van Delft M, Fletcher JI, Puthalakath H, Kuroda J, Michalak EM, Kelly PN, Bouillet P, Villunger A, O'Reilly L, Bath ML, Smith DP, Egle A, Harris AW, Hinds M, Colman P, Cory S. Adams JM, et al. Among authors: van delft m. Cold Spring Harb Symp Quant Biol. 2005;70:469-77. doi: 10.1101/sqb.2005.70.009. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869785

4

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. van Delft MF, et al. Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027. Cancer Cell. 2006. PMID: 17097561 Free PMC article.

5

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: van delft mf. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

6

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM. Kvansakul M, et al. Among authors: van delft mf. Mol Cell. 2007 Mar 23;25(6):933-42. doi: 10.1016/j.molcel.2007.02.004. Mol Cell. 2007. PMID: 17386268 Free article.

7

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee EF, Czabotar PE, van Delft MF, Michalak EM, Boyle MJ, Willis SN, Puthalakath H, Bouillet P, Colman PM, Huang DC, Fairlie WD. Lee EF, et al. Among authors: van delft mf. J Cell Biol. 2008 Jan 28;180(2):341-55. doi: 10.1083/jcb.200708096. Epub 2008 Jan 21. J Cell Biol. 2008. PMID: 18209102 Free PMC article.

8

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases.

van Delft MF, Smith DP, Lahoud MH, Huang DC, Adams JM. van Delft MF, et al. Cell Death Differ. 2010 May;17(5):821-32. doi: 10.1038/cdd.2009.166. Epub 2009 Nov 13. Cell Death Differ. 2010. PMID: 19911005 Free PMC article.

9

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, Wei A, Huang DC, Colman PM, Street IP, Baell JB, Watson K, Lessene G. Sleebs BE, et al. Among authors: van delft mf. J Med Chem. 2013 Jul 11;56(13):5514-40. doi: 10.1021/jm400556w. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23767404

10

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

Okamoto T, Coultas L, Metcalf D, van Delft MF, Glaser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Huang DC. Okamoto T, et al. Among authors: van delft mf. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6. doi: 10.1073/pnas.1321259110. Epub 2013 Dec 20. Proc Natl Acad Sci U S A. 2014. PMID: 24363325 Free PMC article.

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