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Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa.
John CC, O'Donnell RA, Sumba PO, Moormann AM, de Koning-Ward TF, King CL, Kazura JW, Crabb BS. John CC, et al. J Immunol. 2004 Jul 1;173(1):666-72. doi: 10.4049/jimmunol.173.1.666. J Immunol. 2004. PMID: 15210830
Editorial: Molecular Approaches to Malaria 2020.
de Koning-Ward TF, Boddey JA, Fowkes FJI. de Koning-Ward TF, et al. Int J Parasitol. 2022 Oct;52(11):705-706. doi: 10.1016/j.ijpara.2022.11.001. Int J Parasitol. 2022. PMID: 36460364 No abstract available.
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Nguyen W, Boulet C, Dans MG, Loi K, Jarman KE, Watson GM, Tham WH, Fairhurst KJ, Yeo T, Fidock DA, Wittlin S, Chowdury M, de Koning-Ward TF, Chen G, Yan D, Charman SA, Baud D, Brand S, Jackson PF, Cowman AF, Gilson PR, Sleebs BE. Nguyen W, et al. Among authors: de koning ward tf. Eur J Med Chem. 2024 Apr 15;270:116354. doi: 10.1016/j.ejmech.2024.116354. Epub 2024 Mar 25. Eur J Med Chem. 2024. PMID: 38554474 Free article.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: de koning ward tf. mBio. 2024 Jun 12;15(6):e0096624. doi: 10.1128/mbio.00966-24. Epub 2024 May 8. mBio. 2024. PMID: 38717141 Free PMC article.
101 results