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Single-chain antibodies as new antithrombotic drugs.
Hagemeyer CE, Schwarz M, Peter K. Hagemeyer CE, et al. Semin Thromb Hemost. 2007 Mar;33(2):185-95. doi: 10.1055/s-2007-969033. Semin Thromb Hemost. 2007. PMID: 17340468 Review.
HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi.
Ahrens I, Chen YC, Topcic D, Bode M, Haenel D, Hagemeyer CE, Seeba H, Duerschmied D, Bassler N, Jandeleit-Dahm KA, Sweet MJ, Agrotis A, Bobik A, Peter K. Ahrens I, et al. Among authors: hagemeyer ce. Thromb Haemost. 2015 Nov;114(5):994-1003. doi: 10.1160/TH14-12-1073. Epub 2015 Jul 23. Thromb Haemost. 2015. PMID: 26202300
Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation.
Stoll P, Bassler N, Hagemeyer CE, Eisenhardt SU, Chen YC, Schmidt R, Schwarz M, Ahrens I, Katagiri Y, Pannen B, Bode C, Peter K. Stoll P, et al. Among authors: hagemeyer ce. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1206-12. doi: 10.1161/ATVBAHA.106.138875. Epub 2007 Feb 22. Arterioscler Thromb Vasc Biol. 2007. PMID: 17322097
107 results