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An integrative genomics approach to infer causal associations between gene expression and disease.
Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ. Schadt EE, et al. Among authors: lum py. Nat Genet. 2005 Jul;37(7):710-7. doi: 10.1038/ng1589. Epub 2005 Jun 19. Nat Genet. 2005. PMID: 15965475 Free PMC article.
Mapping the genetic architecture of gene expression in human liver.
Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R. Schadt EE, et al. Among authors: lum py. PLoS Biol. 2008 May 6;6(5):e107. doi: 10.1371/journal.pbio.0060107. PLoS Biol. 2008. PMID: 18462017 Free PMC article.
Integrative genomics and drug development.
Lum PY, Derry JM, Schadt EE. Lum PY, et al. Pharmacogenomics. 2009 Feb;10(2):203-12. doi: 10.2217/14622416.10.2.203. Pharmacogenomics. 2009. PMID: 19207021 Review.
Variations in DNA elucidate molecular networks that cause disease.
Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE. Chen Y, et al. Among authors: lum py. Nature. 2008 Mar 27;452(7186):429-35. doi: 10.1038/nature06757. Epub 2008 Mar 16. Nature. 2008. PMID: 18344982 Free PMC article.
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, Lum PY. Yang X, et al. Among authors: lum py. Genome Res. 2010 Aug;20(8):1020-36. doi: 10.1101/gr.103341.109. Epub 2010 Jun 10. Genome Res. 2010. PMID: 20538623 Free PMC article.
60 results