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Page 1
Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers.
Wu S, Fluxe A, Sheffer J, Janusz JM, Blass BE, White R, Jackson C, Hedges R, Murawsky M, Fang B, Fadayel GM, Hare M, Djandjighian L. Wu S, et al. Among authors: djandjighian l. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6213-8. doi: 10.1016/j.bmcl.2006.09.021. Epub 2006 Sep 28. Bioorg Med Chem Lett. 2006. PMID: 17010606
Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.
Blass BE, Fensome A, Trybulski E, Magolda R, Gardell SJ, Liu K, Samuel M, Feingold I, Huselton C, Jackson CM, Djandjighian L, Ho D, Hennan J, Janusz JM. Blass BE, et al. Among authors: djandjighian l. J Med Chem. 2009 Nov 12;52(21):6531-4. doi: 10.1021/jm901042m. J Med Chem. 2009. PMID: 19888755
Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.
Blass BE, Coburn K, Lee W, Fairweather N, Fluxe A, Wu S, Janusz JM, Murawsky M, Fadayel GM, Fang B, Hare M, Ridgeway J, White R, Jackson C, Djandjighian L, Hedges R, Wireko FC, Ritter AL. Blass BE, et al. Among authors: djandjighian l. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4629-32. doi: 10.1016/j.bmcl.2006.06.001. Epub 2006 Jun 21. Bioorg Med Chem Lett. 2006. PMID: 16793267