Walsh TR - Search Results

1

Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.

Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW. Crawford PA, et al. Among authors: walsh tr. Protein Expr Purif. 2004 Aug;36(2):272-9. doi: 10.1016/j.pep.2004.04.017. Protein Expr Purif. 2004. PMID: 15249050

2

Characterization of monomeric L1 metallo-beta -lactamase and the role of the N-terminal extension in negative cooperativity and antibiotic hydrolysis.

Simm AM, Higgins CS, Carenbauer AL, Crowder MW, Bateson JH, Bennett PM, Clarke AR, Halford SE, Walsh TR. Simm AM, et al. Among authors: walsh tr. J Biol Chem. 2002 Jul 5;277(27):24744-52. doi: 10.1074/jbc.M201524200. Epub 2002 Apr 8. J Biol Chem. 2002. PMID: 11940588 Free article.

3

A new approach to the inhibition of metallo-beta-lactamases.

Spencer J, Walsh TR. Spencer J, et al. Among authors: walsh tr. Angew Chem Int Ed Engl. 2006 Feb 6;45(7):1022-6. doi: 10.1002/anie.200502984. Angew Chem Int Ed Engl. 2006. PMID: 16404761 Review. No abstract available.

4

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.

Samuelsen Ø, Castanheira M, Walsh TR, Spencer J. Samuelsen Ø, et al. Among authors: walsh tr. Antimicrob Agents Chemother. 2008 Aug;52(8):2905-8. doi: 10.1128/AAC.00166-08. Epub 2008 Jun 16. Antimicrob Agents Chemother. 2008. PMID: 18559652 Free PMC article.

5

Crystal structure of the mobile metallo-β-lactamase AIM-1 from Pseudomonas aeruginosa: insights into antibiotic binding and the role of Gln157.

Leiros HK, Borra PS, Brandsdal BO, Edvardsen KS, Spencer J, Walsh TR, Samuelsen O. Leiros HK, et al. Among authors: walsh tr. Antimicrob Agents Chemother. 2012 Aug;56(8):4341-53. doi: 10.1128/AAC.00448-12. Epub 2012 Jun 4. Antimicrob Agents Chemother. 2012. PMID: 22664968 Free PMC article.

6

Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.

Murphy TA, Catto LE, Halford SE, Hadfield AT, Minor W, Walsh TR, Spencer J. Murphy TA, et al. Among authors: walsh tr. J Mol Biol. 2006 Mar 31;357(3):890-903. doi: 10.1016/j.jmb.2006.01.003. Epub 2006 Jan 23. J Mol Biol. 2006. PMID: 16460758

7

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J. Salimraj R, et al. Among authors: walsh tr. FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23. FEBS J. 2019. PMID: 30430727 Free PMC article.

8

Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.

Buynak JD, Chen H, Vogeti L, Gadhachanda VR, Buchanan CA, Palzkill T, Shaw RW, Spencer J, Walsh TR. Buynak JD, et al. Among authors: walsh tr. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1299-304. doi: 10.1016/j.bmcl.2003.12.037. Bioorg Med Chem Lett. 2004. PMID: 14980686

9

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Langley GW, et al. Among authors: walsh tr. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17. Bioorg Med Chem Lett. 2019. PMID: 31171422 Free PMC article.

10

Crystal structures of Pseudomonas aeruginosa GIM-1: active-site plasticity in metallo-β-lactamases.

Borra PS, Samuelsen Ø, Spencer J, Walsh TR, Lorentzen MS, Leiros HK. Borra PS, et al. Among authors: walsh tr. Antimicrob Agents Chemother. 2013 Feb;57(2):848-54. doi: 10.1128/AAC.02227-12. Epub 2012 Dec 3. Antimicrob Agents Chemother. 2013. PMID: 23208706 Free PMC article.

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