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Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.
Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow RC, Mann GE, Shoda J, Ishii T, Sakurai T. Harada H, et al. Among authors: uwayama j. J Neurosci. 2013 Sep 11;33(37):14767-77. doi: 10.1523/JNEUROSCI.2954-12.2013. J Neurosci. 2013. PMID: 24027277 Free PMC article.
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. Komatsu M, et al. Among authors: uwayama j. Cell. 2007 Dec 14;131(6):1149-63. doi: 10.1016/j.cell.2007.10.035. Cell. 2007. PMID: 18083104 Free article.