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Fragment-based lead discovery.
Rees DC, Congreve M, Murray CW, Carr R. Rees DC, et al. Among authors: carr r. Nat Rev Drug Discov. 2004 Aug;3(8):660-72. doi: 10.1038/nrd1467. Nat Rev Drug Discov. 2004. PMID: 15286733 Review. No abstract available.
Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H. Gill AL, et al. Among authors: carr mg, carr ra. J Med Chem. 2005 Jan 27;48(2):414-26. doi: 10.1021/jm049575n. J Med Chem. 2005. PMID: 15658855
Fragment-based lead discovery: leads by design.
Carr RA, Congreve M, Murray CW, Rees DC. Carr RA, et al. Drug Discov Today. 2005 Jul 15;10(14):987-92. doi: 10.1016/S1359-6446(05)03511-7. Drug Discov Today. 2005. PMID: 16023057 Review.
A 'rule of three' for fragment-based lead discovery?
Congreve M, Carr R, Murray C, Jhoti H. Congreve M, et al. Among authors: carr r. Drug Discov Today. 2003 Oct 1;8(19):876-7. doi: 10.1016/s1359-6446(03)02831-9. Drug Discov Today. 2003. PMID: 14554012 No abstract available.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
Edwards PD, Albert JS, Sylvester M, Aharony D, Andisik D, Callaghan O, Campbell JB, Carr RA, Chessari G, Congreve M, Frederickson M, Folmer RH, Geschwindner S, Koether G, Kolmodin K, Krumrine J, Mauger RC, Murray CW, Olsson LL, Patel S, Spear N, Tian G. Edwards PD, et al. J Med Chem. 2007 Nov 29;50(24):5912-25. doi: 10.1021/jm070829p. Epub 2007 Nov 7. J Med Chem. 2007. PMID: 17985862
Reporter resins for solid-phase chemistry.
Congreve MS, Ladlow M, Marshall P, Parr N, Scicinski JJ, Sheppard T, Vickerstaffe E, Carr RA. Congreve MS, et al. Among authors: carr ra. Org Lett. 2001 Feb 22;3(4):507-10. doi: 10.1021/ol006751n. Org Lett. 2001. PMID: 11178811
1,422 results