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Page 1
Fragment-based lead discovery.
Rees DC, Congreve M, Murray CW, Carr R. Rees DC, et al. Among authors: congreve m. Nat Rev Drug Discov. 2004 Aug;3(8):660-72. doi: 10.1038/nrd1467. Nat Rev Drug Discov. 2004. PMID: 15286733 Review. No abstract available.
Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H. Gill AL, et al. Among authors: congreve ms. J Med Chem. 2005 Jan 27;48(2):414-26. doi: 10.1021/jm049575n. J Med Chem. 2005. PMID: 15658855
A 'rule of three' for fragment-based lead discovery?
Congreve M, Carr R, Murray C, Jhoti H. Congreve M, et al. Drug Discov Today. 2003 Oct 1;8(19):876-7. doi: 10.1016/s1359-6446(03)02831-9. Drug Discov Today. 2003. PMID: 14554012 No abstract available.
Structural biology and drug discovery.
Congreve M, Murray CW, Blundell TL. Congreve M, et al. Drug Discov Today. 2005 Jul 1;10(13):895-907. doi: 10.1016/S1359-6446(05)03484-7. Drug Discov Today. 2005. PMID: 15993809 Review.
Fragment-based lead discovery: leads by design.
Carr RA, Congreve M, Murray CW, Rees DC. Carr RA, et al. Among authors: congreve m. Drug Discov Today. 2005 Jul 15;10(14):987-92. doi: 10.1016/S1359-6446(05)03511-7. Drug Discov Today. 2005. PMID: 16023057 Review.
Application of fragment screening by X-ray crystallography to beta-secretase.
Murray CW, Callaghan O, Chessari G, Cleasby A, Congreve M, Frederickson M, Hartshorn MJ, McMenamin R, Patel S, Wallis N. Murray CW, et al. Among authors: congreve m. J Med Chem. 2007 Mar 22;50(6):1116-23. doi: 10.1021/jm0611962. Epub 2007 Feb 22. J Med Chem. 2007. PMID: 17315856
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O'Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith DM, Trewartha G, Vinkovic M, Williams B, Woolford AJ. Woodhead AJ, et al. Among authors: congreve m. J Med Chem. 2010 Aug 26;53(16):5956-69. doi: 10.1021/jm100060b. J Med Chem. 2010. PMID: 20662534
74 results