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Page 1
Fragment-based lead discovery.
Rees DC, Congreve M, Murray CW, Carr R. Rees DC, et al. Among authors: murray cw. Nat Rev Drug Discov. 2004 Aug;3(8):660-72. doi: 10.1038/nrd1467. Nat Rev Drug Discov. 2004. PMID: 15286733 Review. No abstract available.
A 'rule of three' for fragment-based lead discovery?
Congreve M, Carr R, Murray C, Jhoti H. Congreve M, et al. Drug Discov Today. 2003 Oct 1;8(19):876-7. doi: 10.1016/s1359-6446(03)02831-9. Drug Discov Today. 2003. PMID: 14554012 No abstract available.
Fragment-based lead discovery using X-ray crystallography.
Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H. Hartshorn MJ, et al. Among authors: murray cw. J Med Chem. 2005 Jan 27;48(2):403-13. doi: 10.1021/jm0495778. J Med Chem. 2005. PMID: 15658854
Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H. Gill AL, et al. Among authors: murray cw. J Med Chem. 2005 Jan 27;48(2):414-26. doi: 10.1021/jm049575n. J Med Chem. 2005. PMID: 15658855
Structural biology and drug discovery.
Congreve M, Murray CW, Blundell TL. Congreve M, et al. Among authors: murray cw. Drug Discov Today. 2005 Jul 1;10(13):895-907. doi: 10.1016/S1359-6446(05)03484-7. Drug Discov Today. 2005. PMID: 15993809 Review.
Fragment-based lead discovery: leads by design.
Carr RA, Congreve M, Murray CW, Rees DC. Carr RA, et al. Among authors: murray cw. Drug Discov Today. 2005 Jul 15;10(14):987-92. doi: 10.1016/S1359-6446(05)03511-7. Drug Discov Today. 2005. PMID: 16023057 Review.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
Edwards PD, Albert JS, Sylvester M, Aharony D, Andisik D, Callaghan O, Campbell JB, Carr RA, Chessari G, Congreve M, Frederickson M, Folmer RH, Geschwindner S, Koether G, Kolmodin K, Krumrine J, Mauger RC, Murray CW, Olsson LL, Patel S, Spear N, Tian G. Edwards PD, et al. Among authors: murray cw. J Med Chem. 2007 Nov 29;50(24):5912-25. doi: 10.1021/jm070829p. Epub 2007 Nov 7. J Med Chem. 2007. PMID: 17985862
104 results