Hoffmaster KA - Search Results

1

Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.

Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Hoffmaster KA, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1203-10. doi: 10.1124/jpet.104.070201. Epub 2004 Aug 9. J Pharmacol Exp Ther. 2004. PMID: 15302892

2

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. Hoffmaster KA, et al. Pharm Res. 2004 Jul;21(7):1294-302. doi: 10.1023/b:pham.0000033018.97745.0d. Pharm Res. 2004. PMID: 15290872

3

Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin.

Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Hoffmaster KA, et al. Drug Metab Dispos. 2005 Feb;33(2):287-93. doi: 10.1124/dmd.104.001420. Epub 2004 Nov 4. Drug Metab Dispos. 2005. PMID: 15528320

4

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, Zhao R, Polli JW, Humphreys JE, Webster LO, Bridges AS, Kalvass JC, Brouwer KL. Zamek-Gliszczynski MJ, et al. Among authors: hoffmaster ka. Drug Metab Dispos. 2005 Aug;33(8):1158-65. doi: 10.1124/dmd.104.002188. Epub 2005 Apr 28. Drug Metab Dispos. 2005. PMID: 15860656

5

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.

Turncliff RZ, Hoffmaster KA, Kalvass JC, Pollack GM, Brouwer KL. Turncliff RZ, et al. Among authors: hoffmaster ka. J Pharmacol Exp Ther. 2006 Aug;318(2):881-9. doi: 10.1124/jpet.106.102616. Epub 2006 May 11. J Pharmacol Exp Ther. 2006. PMID: 16690724 Free article.

6

Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.

Zamek-Gliszczynski MJ, Hoffmaster KA, Humphreys JE, Tian X, Nezasa K, Brouwer KL. Zamek-Gliszczynski MJ, et al. Among authors: hoffmaster ka. J Pharmacol Exp Ther. 2006 Oct;319(1):459-67. doi: 10.1124/jpet.106.101840. Epub 2006 Jul 20. J Pharmacol Exp Ther. 2006. PMID: 16857726

7

Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.

Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Brouwer KL. Zamek-Gliszczynski MJ, et al. Among authors: hoffmaster ka. Drug Metab Dispos. 2008 Nov;36(11):2156-8. doi: 10.1124/dmd.108.022053. Epub 2008 Aug 21. Drug Metab Dispos. 2008. PMID: 18719241 Free PMC article.

8

Highlights from the International Transporter Consortium second workshop.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM. Zamek-Gliszczynski MJ, et al. Among authors: hoffmaster ka. Clin Pharmacol Ther. 2012 Nov;92(5):553-6. doi: 10.1038/clpt.2012.126. Clin Pharmacol Ther. 2012. PMID: 23085880

9

In vitro methods to support transporter evaluation in drug discovery and development.

Brouwer KL, Keppler D, Hoffmaster KA, Bow DA, Cheng Y, Lai Y, Palm JE, Stieger B, Evers R; International Transporter Consortium. Brouwer KL, et al. Among authors: hoffmaster ka. Clin Pharmacol Ther. 2013 Jul;94(1):95-112. doi: 10.1038/clpt.2013.81. Epub 2013 Apr 10. Clin Pharmacol Ther. 2013. PMID: 23588315 Free article. Review.

10

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.

Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL. Zamek-Gliszczynski MJ, et al. Among authors: hoffmaster ka. Eur J Pharm Sci. 2006 Apr;27(5):447-86. doi: 10.1016/j.ejps.2005.12.007. Epub 2006 Feb 10. Eur J Pharm Sci. 2006. PMID: 16472997 Review.

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