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Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.
Park DS, Woodman SE, Schubert W, Cohen AW, Frank PG, Chandra M, Shirani J, Razani B, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP. Park DS, et al. Among authors: tanowitz hb. Am J Pathol. 2002 Jun;160(6):2207-17. doi: 10.1016/S0002-9440(10)61168-6. Am J Pathol. 2002. PMID: 12057923 Free PMC article.
Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts.
Cohen AW, Park DS, Woodman SE, Williams TM, Chandra M, Shirani J, Pereira de Souza A, Kitsis RN, Russell RG, Weiss LM, Tang B, Jelicks LA, Factor SM, Shtutin V, Tanowitz HB, Lisanti MP. Cohen AW, et al. Among authors: tanowitz hb. Am J Physiol Cell Physiol. 2003 Feb;284(2):C457-74. doi: 10.1152/ajpcell.00380.2002. Epub 2002 Oct 9. Am J Physiol Cell Physiol. 2003. PMID: 12388077 Free article.
Caveolin-1 null (-/-) mice show dramatic reductions in life span.
Park DS, Cohen AW, Frank PG, Razani B, Lee H, Williams TM, Chandra M, Shirani J, De Souza AP, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP. Park DS, et al. Among authors: tanowitz hb. Biochemistry. 2003 Dec 30;42(51):15124-31. doi: 10.1021/bi0356348. Biochemistry. 2003. PMID: 14690422
Impaired phagocytosis in caveolin-1 deficient macrophages.
Li J, Scherl A, Medina F, Frank PG, Kitsis RN, Tanowitz HB, Sotgia F, Lisanti MP. Li J, et al. Among authors: tanowitz hb. Cell Cycle. 2005 Nov;4(11):1599-607. doi: 10.4161/cc.4.11.2117. Epub 2005 Nov 23. Cell Cycle. 2005. PMID: 16205123
Cyclin and caveolin expression in an acute model of murine Chagasic myocarditis.
Nagajyothi F, Desruisseaux M, Bouzahzah B, Weiss LM, Andrade Ddos S, Factor SM, Scherer PE, Albanese C, Lisanti MP, Tanowitz HB. Nagajyothi F, et al. Among authors: tanowitz hb. Cell Cycle. 2006 Jan;5(1):107-12. doi: 10.4161/cc.5.1.2284. Epub 2006 Jan 28. Cell Cycle. 2006. PMID: 16319533
344 results