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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations.
Ma Y, Zeng S, Metcalfe DD, Akin C, Dimitrijevic S, Butterfield JH, McMahon G, Longley BJ. Ma Y, et al. Among authors: zeng s. Blood. 2002 Mar 1;99(5):1741-4. doi: 10.1182/blood.v99.5.1741. Blood. 2002. PMID: 11861291 Free article.
Opposing roles of RAGE and Myd88 signaling in extensive liver resection.
Zeng S, Zhang QY, Huang J, Vedantham S, Rosario R, Ananthakrishnan R, Yan SF, Ramasamy R, DeMatteo RP, Emond JC, Friedman RA, Schmidt AM. Zeng S, et al. FASEB J. 2012 Feb;26(2):882-93. doi: 10.1096/fj.11-192997. Epub 2011 Nov 10. FASEB J. 2012. PMID: 22075646 Free PMC article.
Nilotinib protects the murine liver from ischemia/reperfusion injury.
Ocuin LM, Zeng S, Cavnar MJ, Sorenson EC, Bamboat ZM, Greer JB, Kim TS, Popow R, DeMatteo RP. Ocuin LM, et al. Among authors: zeng s. J Hepatol. 2012 Oct;57(4):766-73. doi: 10.1016/j.jhep.2012.05.012. Epub 2012 May 26. J Hepatol. 2012. PMID: 22641092 Free PMC article.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
Balachandran VP, Cavnar MJ, Zeng S, Bamboat ZM, Ocuin LM, Obaid H, Sorenson EC, Popow R, Ariyan C, Rossi F, Besmer P, Guo T, Antonescu CR, Taguchi T, Yuan J, Wolchok JD, Allison JP, DeMatteo RP. Balachandran VP, et al. Among authors: zeng s. Nat Med. 2011 Aug 28;17(9):1094-100. doi: 10.1038/nm.2438. Nat Med. 2011. PMID: 21873989 Free PMC article.
KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
Cavnar MJ, Zeng S, Kim TS, Sorenson EC, Ocuin LM, Balachandran VP, Seifert AM, Greer JB, Popow R, Crawley MH, Cohen NA, Green BL, Rossi F, Besmer P, Antonescu CR, DeMatteo RP. Cavnar MJ, et al. Among authors: zeng s. J Exp Med. 2013 Dec 16;210(13):2873-86. doi: 10.1084/jem.20130875. Epub 2013 Dec 9. J Exp Med. 2013. PMID: 24323358 Free PMC article.
4,712 results