Seiler SM - Search Results

1

Peptide-derived protease-activated receptor-1 (PAR-1) antagonists.

Seiler SM, Bernatowicz MS. Seiler SM, et al. Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):1-11. doi: 10.2174/1568016033356689. Curr Med Chem Cardiovasc Hematol Agents. 2003. PMID: 15317287 Review.

2

Development of potent thrombin receptor antagonist peptides.

Bernatowicz MS, Klimas CE, Hartl KS, Peluso M, Allegretto NJ, Seiler SM. Bernatowicz MS, et al. Among authors: seiler sm. J Med Chem. 1996 Dec 6;39(25):4879-87. doi: 10.1021/jm960455s. J Med Chem. 1996. PMID: 8960546

3

Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists.

Seiler SM, Peluso M, Tuttle JG, Pryor K, Klimas C, Matsueda GR, Bernatowicz MS. Seiler SM, et al. Mol Pharmacol. 1996 Jan;49(1):190-7. Mol Pharmacol. 1996. PMID: 8569706

4

Thrombin receptor antagonists.

Seiler SM. Seiler SM. Semin Thromb Hemost. 1996;22(3):223-32. doi: 10.1055/s-2007-999012. Semin Thromb Hemost. 1996. PMID: 8836006 Review.

5

Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.

Iwanowicz EJ, Kimball SD, Lin J, Lau W, Han WC, Wang TC, Roberts DG, Schumacher WA, Ogletree ML, Seiler SM. Iwanowicz EJ, et al. Among authors: seiler sm. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3183-6. doi: 10.1016/s0960-894x(02)00651-0. Bioorg Med Chem Lett. 2002. PMID: 12372529

6

Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.

Das J, Kimball SD, Hall SE, Han WC, Iwanowicz E, Lin J, Moquin RV, Reid JA, Sack JS, Malley MF, Chang CY, Chong S, Wang-Iverson DB, Roberts DG, Seiler SM, Schumacher WA, Ogletree ML. Das J, et al. Among authors: seiler sm. Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9. doi: 10.1016/s0960-894x(01)00667-9. Bioorg Med Chem Lett. 2002. PMID: 11738570

7

'Tethered ligand' derived pentapeptide agonists of thrombin receptor: a study of side chain requirements for human platelet activation and GTPase stimulation.

Natarajan S, Riexinger D, Peluso M, Seiler SM. Natarajan S, et al. Among authors: seiler sm. Int J Pept Protein Res. 1995 Feb;45(2):145-51. doi: 10.1111/j.1399-3011.1995.tb01033.x. Int J Pept Protein Res. 1995. PMID: 7782162

8

Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.

Das J, Kimball SD, Reid JA, Wang TC, Lau WF, Roberts DG, Seiler SM, Schumacher WA, Ogletree ML. Das J, et al. Among authors: seiler sm. Bioorg Med Chem Lett. 2002 Jan 7;12(1):41-4. doi: 10.1016/s0960-894x(01)00664-3. Bioorg Med Chem Lett. 2002. PMID: 11738569

9

Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic.

Meanwell NA, Rosenfeld MJ, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Seiler SM. Meanwell NA, et al. Among authors: seiler sm. J Med Chem. 1992 Jan 24;35(2):389-97. doi: 10.1021/jm00080a028. J Med Chem. 1992. PMID: 1370696

10

Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist.

Seiler SM, Peluso M, Michel IM, Goldenberg H, Fenton JW 2nd, Riexinger D, Natarajan S. Seiler SM, et al. Biochem Pharmacol. 1995 Feb 14;49(4):519-28. doi: 10.1016/0006-2952(94)00473-y. Biochem Pharmacol. 1995. PMID: 7872957

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