McGuigan C - Search Results

1

Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels.

Balzarini J, Aquaro S, Hassan-Abdallah A, Daluge SM, Perno CF, McGuigan C. Balzarini J, et al. Among authors: mcguigan c. FEBS Lett. 2004 Aug 27;573(1-3):38-44. doi: 10.1016/j.febslet.2004.07.049. FEBS Lett. 2004. PMID: 15327972 Free article.

2

Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

Balzarini J, Kruining J, Wedgwood O, Pannecouque C, Aquaro S, Perno CF, Naesens L, Witvrouw M, Heijtink R, De Clercq E, McGuigan C. Balzarini J, et al. Among authors: mcguigan c. FEBS Lett. 1997 Jun 30;410(2-3):324-8. doi: 10.1016/s0014-5793(97)00616-9. FEBS Lett. 1997. PMID: 9237655 Free article.

3

Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication.

Balzarini J, McGuigan C. Balzarini J, et al. Among authors: mcguigan c. J Antimicrob Chemother. 2002 Jul;50(1):5-9. doi: 10.1093/jac/dkf037. J Antimicrob Chemother. 2002. PMID: 12096000 Review.

4

Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.

McGuigan C, Harris SA, Daluge SM, Gudmundsson KS, McLean EW, Burnette TC, Marr H, Hazen R, Condreay LD, Johnson L, De Clercq E, Balzarini J. McGuigan C, et al. J Med Chem. 2005 May 19;48(10):3504-15. doi: 10.1021/jm0491400. J Med Chem. 2005. PMID: 15887959

5

Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives.

McGuigan C, Hassan-Abdallah A, Srinivasan S, Wang Y, Siddiqui A, Daluge SM, Gudmundsson KS, Zhou H, McLean EW, Peckham JP, Burnette TC, Marr H, Hazen R, Condreay LD, Johnson L, Balzarini J. McGuigan C, et al. J Med Chem. 2006 Nov 30;49(24):7215-26. doi: 10.1021/jm060776w. J Med Chem. 2006. PMID: 17125274

6

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.

Vande Voorde J, Liekens S, McGuigan C, Murziani PG, Slusarczyk M, Balzarini J. Vande Voorde J, et al. Among authors: mcguigan c. Biochem Pharmacol. 2011 Sep 1;82(5):441-52. doi: 10.1016/j.bcp.2011.05.024. Epub 2011 May 31. Biochem Pharmacol. 2011. PMID: 21658373 Free article.

7

Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides.

Velanguparackel W, Hamon N, Balzarini J, McGuigan C, Westwell AD. Velanguparackel W, et al. Among authors: mcguigan c. Bioorg Med Chem Lett. 2014 May 15;24(10):2240-3. doi: 10.1016/j.bmcl.2014.03.092. Epub 2014 Apr 5. Bioorg Med Chem Lett. 2014. PMID: 24751439

8

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

Balzarini J, Karlsson A, Aquaro S, Perno CF, Cahard D, Naesens L, De Clercq E, McGuigan C. Balzarini J, et al. Among authors: mcguigan c. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7295-9. doi: 10.1073/pnas.93.14.7295. Proc Natl Acad Sci U S A. 1996. PMID: 8692986 Free PMC article.

9

Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety.

Naesens L, Cahard D, Salgado A, Bidois L, De Clercq E, McGuigan C, Balzarini J. Naesens L, et al. Among authors: mcguigan c. Adv Exp Med Biol. 1998;431:753-7. doi: 10.1007/978-1-4615-5381-6_144. Adv Exp Med Biol. 1998. PMID: 9598164

10

Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides.

Balzarini J, McGuigan C. Balzarini J, et al. Among authors: mcguigan c. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):287-95. doi: 10.1016/s0925-4439(02)00091-1. Biochim Biophys Acta. 2002. PMID: 12084470 Free article. Review.

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