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Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF. Jager J, et al. Diabetes. 2010 Jan;59(1):61-70. doi: 10.2337/db09-0470. Epub 2009 Oct 6. Diabetes. 2010. PMID: 19808894 Free PMC article.
Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.
Regazzetti C, Dumas K, Lacas-Gervais S, Pastor F, Peraldi P, Bonnafous S, Dugail I, Le Lay S, Valet P, Le Marchand-Brustel Y, Tran A, Gual P, Tanti JF, Cormont M, Giorgetti-Peraldi S. Regazzetti C, et al. Among authors: le marchand brustel y. Endocrinology. 2015 Mar;156(3):789-801. doi: 10.1210/en.2014-1656. Epub 2014 Dec 18. Endocrinology. 2015. PMID: 25521582
Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.
Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P. Bertola A, et al. Diabetes. 2009 Jan;58(1):125-33. doi: 10.2337/db08-0400. Epub 2008 Oct 24. Diabetes. 2009. PMID: 18952835 Free PMC article.
162 results