Chiang GG - Search Results

1

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.

Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. Knight ZA, et al. Among authors: chiang gg. Bioorg Med Chem. 2004 Sep 1;12(17):4749-59. doi: 10.1016/j.bmc.2004.06.022. Bioorg Med Chem. 2004. PMID: 15358300

2

Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family.

Chiang GG, Abraham RT. Chiang GG, et al. Methods Mol Biol. 2004;281:125-41. doi: 10.1385/1-59259-811-0:125. Methods Mol Biol. 2004. PMID: 15220525

3

Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin.

Wipf P, Minion DJ, Halter RJ, Berggren MI, Ho CB, Chiang GG, Kirkpatrick L, Abraham R, Powis G. Wipf P, et al. Among authors: chiang gg. Org Biomol Chem. 2004 Jul 7;2(13):1911-20. doi: 10.1039/b405431h. Epub 2004 Jun 14. Org Biomol Chem. 2004. PMID: 15227545

4

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

Chiang GG, Abraham RT. Chiang GG, et al. J Biol Chem. 2005 Jul 8;280(27):25485-90. doi: 10.1074/jbc.M501707200. Epub 2005 May 16. J Biol Chem. 2005. PMID: 15899889 Free article.

5

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.

Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, Abraham RT. Howes AL, et al. Among authors: chiang gg. Mol Cancer Ther. 2007 Sep;6(9):2505-14. doi: 10.1158/1535-7163.MCT-06-0698. Epub 2007 Aug 31. Mol Cancer Ther. 2007. PMID: 17766839

6

Targeting the mTOR signaling network in cancer.

Chiang GG, Abraham RT. Chiang GG, et al. Trends Mol Med. 2007 Oct;13(10):433-42. doi: 10.1016/j.molmed.2007.08.001. Epub 2007 Oct 1. Trends Mol Med. 2007. PMID: 17905659 Review.

7

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Hudson CC, et al. Among authors: chiang gg. Mol Cell Biol. 2002 Oct;22(20):7004-14. doi: 10.1128/MCB.22.20.7004-7014.2002. Mol Cell Biol. 2002. PMID: 12242281 Free PMC article.

8

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT. Zhang YW, et al. Among authors: chiang gg. Mol Cell. 2005 Sep 2;19(5):607-18. doi: 10.1016/j.molcel.2005.07.019. Mol Cell. 2005. PMID: 16137618 Free article.

9

The FRB domain of mTOR: NMR solution structure and inhibitor design.

Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M. Leone M, et al. Among authors: chiang gg. Biochemistry. 2006 Aug 29;45(34):10294-302. doi: 10.1021/bi060976+. Biochemistry. 2006. PMID: 16922504

10

Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.

Lau E, Chiang GG, Abraham RT, Jiang W. Lau E, et al. Among authors: chiang gg. Mol Biol Cell. 2009 Sep;20(17):3953-64. doi: 10.1091/mbc.e09-01-0022. Epub 2009 Jul 8. Mol Biol Cell. 2009. PMID: 19587119 Free PMC article.

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