Clapham JC - Search Results

1

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.

Pearce NJ, Arch JR, Clapham JC, Coghlan MP, Corcoran SL, Lister CA, Llano A, Moore GB, Murphy GJ, Smith SA, Taylor CM, Yates JW, Morrison AD, Harper AJ, Roxbee-Cox L, Abuin A, Wargent E, Holder JC. Pearce NJ, et al. Among authors: clapham jc. Metabolism. 2004 Oct;53(10):1322-30. doi: 10.1016/j.metabol.2004.05.008. Metabolism. 2004. PMID: 15375789

2

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.

Haynes AC, Chapman H, Taylor C, Moore GB, Cawthorne MA, Tadayyon M, Clapham JC, Arch JR. Haynes AC, et al. Among authors: clapham jc. Regul Pept. 2002 Mar 15;104(1-3):153-9. doi: 10.1016/s0167-0115(01)00358-5. Regul Pept. 2002. PMID: 11830290

3

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.

Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A. Clapham JC, et al. Nature. 2000 Jul 27;406(6794):415-8. doi: 10.1038/35019082. Nature. 2000. PMID: 10935638

4

Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA.

Moore GB, Himms-Hagen J, Harper ME, Clapham JC. Moore GB, et al. Among authors: clapham jc. Biochem Biophys Res Commun. 2001 May 18;283(4):785-90. doi: 10.1006/bbrc.2001.4848. Biochem Biophys Res Commun. 2001. PMID: 11350053

5

Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.

Moore GB, Chapman H, Holder JC, Lister CA, Piercy V, Smith SA, Clapham JC. Moore GB, et al. Among authors: clapham jc. Biochem Biophys Res Commun. 2001 Aug 31;286(4):735-41. doi: 10.1006/bbrc.2001.5460. Biochem Biophys Res Commun. 2001. PMID: 11520059

6

Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice.

Clapham JC, Coulthard VH, Moore GB. Clapham JC, et al. Biochem Biophys Res Commun. 2001 Oct 12;287(5):1058-62. doi: 10.1006/bbrc.2001.5698. Biochem Biophys Res Commun. 2001. PMID: 11587528

7

Plasma leptin concentrations and OB gene expression in subcutaneous adipose tissue are not regulated acutely by physiological hyperinsulinaemia in lean and obese humans.

Clapham JC, Smith SA, Moore GB, Hughes MG, Azam H, Scott A, Jung RT. Clapham JC, et al. Int J Obes Relat Metab Disord. 1997 Mar;21(3):179-83. doi: 10.1038/sj.ijo.0800384. Int J Obes Relat Metab Disord. 1997. PMID: 9080255

8

Energy restriction enhances therapeutic efficacy of the PPARgamma agonist, rosiglitazone, through regulation of visceral fat gene expression.

Moore GB, Pickavance LC, Briscoe CP, Clapham JC, Buckingham RE, Wilding JP. Moore GB, et al. Among authors: clapham jc. Diabetes Obes Metab. 2008 Mar;10(3):251-63. doi: 10.1111/j.1463-1326.2007.00697.x. Diabetes Obes Metab. 2008. PMID: 18269641

9

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.

Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. Young PW, et al. Among authors: clapham jc. J Pharmacol Exp Ther. 1998 Feb;284(2):751-9. J Pharmacol Exp Ther. 1998. PMID: 9454824

10

Anti-obesity drugs: a critical review of current therapies and future opportunities.

Clapham JC, Arch JR, Tadayyon M. Clapham JC, et al. Pharmacol Ther. 2001 Jan;89(1):81-121. doi: 10.1016/s0163-7258(00)00105-4. Pharmacol Ther. 2001. PMID: 11316515 Review.

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