Alvarez-Sánchez R - Search Results

1

Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin: identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption/ionization mass spectrometry, and nanoelectrospray tandem mass spectrometry.

Alvarez-Sánchez R, Divkovic M, Basketter D, Pease C, Panico M, Dell A, Morris H, Lepoittevin JP. Alvarez-Sánchez R, et al. Chem Res Toxicol. 2004 Sep;17(9):1280-8. doi: 10.1021/tx049935+. Chem Res Toxicol. 2004. PMID: 15377163

2

Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI).

Alvarez-Sánchez R, Basketter D, Pease C, Lepoittevin JP. Alvarez-Sánchez R, et al. Chem Res Toxicol. 2003 May;16(5):627-36. doi: 10.1021/tx0256634. Chem Res Toxicol. 2003. PMID: 12755592

3

Covalent binding of the 13C-labeled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione.

Alvarez-Sánchez R, Basketter D, Pease C, Lepoittevin JP. Alvarez-Sánchez R, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):365-8. doi: 10.1016/j.bmcl.2003.11.002. Bioorg Med Chem Lett. 2004. PMID: 14698160

4

Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.

Alvarez-Sanchez R, Montavon F, Hartung T, Pähler A. Alvarez-Sanchez R, et al. Chem Res Toxicol. 2006 Aug;19(8):1106-16. doi: 10.1021/tx050353h. Chem Res Toxicol. 2006. PMID: 16918252

5

Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats.

Völkel W, Alvarez-Sánchez R, Weick I, Mally A, Dekant W, Pähler A. Völkel W, et al. Free Radic Biol Med. 2005 Jun 1;38(11):1526-36. doi: 10.1016/j.freeradbiomed.2005.02.015. Free Radic Biol Med. 2005. PMID: 15890627

6

Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.

Martin RE, Mohr P, Maerki HP, Guba W, Kuratli C, Gavelle O, Binggeli A, Bendels S, Alvarez-Sánchez R, Alker A, Polonchuk L, Christ AD. Martin RE, et al. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6106-13. doi: 10.1016/j.bmcl.2009.09.024. Epub 2009 Sep 12. Bioorg Med Chem Lett. 2009. PMID: 19786348

7

Use of the Distribution Coefficient in Brain Polar Lipids for the Assessment of Drug-Induced Phospholipidosis Risk.

Ceccarelli M, Wagner B, Alvarez-Sánchez R, Cruciani G, Goracci L. Ceccarelli M, et al. Chem Res Toxicol. 2017 May 15;30(5):1145-1156. doi: 10.1021/acs.chemrestox.6b00459. Epub 2017 Apr 25. Chem Res Toxicol. 2017. PMID: 28398727

8

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.

Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E. Hebeisen P, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3237-42. doi: 10.1016/j.bmcl.2011.04.044. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21550236

9

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134

10

2-Phenoxy-nicotinamides are potent agonists at the bile acid receptor GPBAR1 (TGR5).

Martin RE, Bissantz C, Gavelle O, Kuratli C, Dehmlow H, Richter HG, Obst Sander U, Erickson SD, Kim K, Pietranico-Cole SL, Alvarez-Sánchez R, Ullmer C. Martin RE, et al. ChemMedChem. 2013 Apr;8(4):569-76. doi: 10.1002/cmdc.201200474. Epub 2012 Dec 7. ChemMedChem. 2013. PMID: 23225346

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