Engler H - Search Results

1

Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha.

Engler H, Machemer T, Philopena J, Wen SF, Quijano E, Ramachandra M, Tsai V, Ralston R. Engler H, et al. Virology. 2004 Oct 10;328(1):52-61. doi: 10.1016/j.virol.2004.06.043. Virology. 2004. PMID: 15380358 Free article.

2

Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy.

Demers GW, Johnson DE, Tsai V, Wen SF, Quijano E, Machemer T, Philopena J, Ramachandra M, Howe JA, Shabram P, Ralston R, Engler H. Demers GW, et al. Among authors: engler h. Cancer Res. 2003 Jul 15;63(14):4003-8. Cancer Res. 2003. PMID: 12873998

3

Development of a formulation that enhances gene expression and efficacy following intraperitoneal administration in rabbits and mice.

Engler H, Machemer TR, Schluep T, Wen SF, Quijano E, Wills KN, Harper AE, Maneval DC, Conroy SE. Engler H, et al. Mol Ther. 2003 Apr;7(4):558-64. doi: 10.1016/s1525-0016(03)00057-1. Mol Ther. 2003. PMID: 12727120 Free article.

4

Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses.

Machemer T, Engler H, Tsai V, Lee S, Cannon-Carlson S, Voloch M, Schluep T, Ravindran S, Vellekamp G, Brin E, Cornell D, Sutjipto S, Wen SF, Horn M, Van Rooijen N, Maneval D, Hutchins B, LaFace D. Machemer T, et al. Among authors: engler h. Mol Ther. 2005 Aug;12(2):254-63. doi: 10.1016/j.ymthe.2005.03.007. Mol Ther. 2005. PMID: 16043097 Free article.

5

Identification of polyamides that enhance adenovirus-mediated gene expression in the urothelium.

Connor RJ, Engler H, Machemer T, Philopena JM, Horn MT, Sutjipto S, Maneval DC, Youngster S, Chan TM, Bausch J, McAuliffe JP, Hindsgaul O, Nagabhushan TL. Connor RJ, et al. Among authors: engler h. Gene Ther. 2001 Jan;8(1):41-8. doi: 10.1038/sj.gt.3301348. Gene Ther. 2001. PMID: 11402300

6

Interferon alpha2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers.

Iqbal Ahmed CM, Johnson DE, Demers GW, Engler H, Howe JA, Wills KN, Wen SF, Shinoda J, Beltran J, Nodelman M, Machemer T, Maneval DC, Nagabhushan TL, Sugarman BJ. Iqbal Ahmed CM, et al. Among authors: engler h. Cancer Gene Ther. 2001 Oct;8(10):788-95. doi: 10.1038/sj.cgt.7700364. Cancer Gene Ther. 2001. PMID: 11687902

7

Sustained intravesical interferon protein exposure is achieved using an adenoviral-mediated gene delivery system: a study in rats evaluating dosing regimens.

Connor RJ, Anderson JM, Machemer T, Maneval DC, Engler H. Connor RJ, et al. Among authors: engler h. Urology. 2005 Jul;66(1):224-9. doi: 10.1016/j.urology.2005.02.015. Urology. 2005. PMID: 15992886

8

Ethanol improves adenovirus-mediated gene transfer and expression to the bladder epithelium of rodents.

Engler H, Anderson SC, Machemer TR, Philopena JM, Connor RJ, Wen SF, Maneval DC. Engler H, et al. Urology. 1999 May;53(5):1049-53. doi: 10.1016/s0090-4295(98)00641-4. Urology. 1999. PMID: 10223504

9

Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy.

Ramachandra M, Rahman A, Zou A, Vaillancourt M, Howe JA, Antelman D, Sugarman B, Demers GW, Engler H, Johnson D, Shabram P. Ramachandra M, et al. Among authors: engler h. Nat Biotechnol. 2001 Nov;19(11):1035-41. doi: 10.1038/nbt1101-1035. Nat Biotechnol. 2001. PMID: 11689848

10

A recombinant adenoviral vector expressing full-length human retinoblastoma susceptibility gene inhibits human tumor cell growth.

Demers GW, Harris MP, Wen SF, Engler H, Nielsen LL, Maneval DC. Demers GW, et al. Among authors: engler h. Cancer Gene Ther. 1998 Jul-Aug;5(4):207-14. Cancer Gene Ther. 1998. PMID: 9694072

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