Leurs R - Search Results

1

Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

Terzioglu N, van Rijn RM, Bakker RA, De Esch IJ, Leurs R. Terzioglu N, et al. Among authors: leurs r. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5251-6. doi: 10.1016/j.bmcl.2004.08.035. Bioorg Med Chem Lett. 2004. PMID: 15454206

2

Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.

Vollinga RC, Menge WM, Leurs R, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1995 Jan 20;38(2):266-71. doi: 10.1021/jm00002a008. J Med Chem. 1995. PMID: 7830269

3

Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.

De Esch IJ, Vollinga RC, Goubitz K, Schenk H, Appelberg U, Hacksell U, Lemstra S, Zuiderveld OP, Hoffmann M, Leurs R, Menge WM, Timmerman H. De Esch IJ, et al. Among authors: leurs r. J Med Chem. 1999 Apr 8;42(7):1115-22. doi: 10.1021/jm9810912. J Med Chem. 1999. PMID: 10197956 Free article.

4

Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists.

Bakker RA, Wieland K, Timmerman H, Leurs R. Bakker RA, et al. Among authors: leurs r. Eur J Pharmacol. 2000 Jan 3;387(1):R5-7. doi: 10.1016/s0014-2999(99)00803-1. Eur J Pharmacol. 2000. PMID: 10633171

5

Characterization of the binding site of the histamine H(3) receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide.

Windhorst AD, Timmerman H, Worthington EA, Bijloo GJ, Nederkoorn PH, Menge WM, Leurs R, Herscheid JD. Windhorst AD, et al. Among authors: leurs r. J Med Chem. 2000 May 4;43(9):1754-61. doi: 10.1021/jm981106w. J Med Chem. 2000. PMID: 10794692

6

Constitutive activity of G protein coupled receptors and drug action.

Leurs R, Rodriguez Pena MS, Bakker RA, Alewijnse AE, Timmerman H. Leurs R, et al. Pharm Acta Helv. 2000 Mar;74(2-3):327-31. doi: 10.1016/s0031-6865(99)00042-4. Pharm Acta Helv. 2000. PMID: 10812977 Review. No abstract available.

7

Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28.

Casarosa P, Bakker RA, Verzijl D, Navis M, Timmerman H, Leurs R, Smit MJ. Casarosa P, et al. Among authors: leurs r. J Biol Chem. 2001 Jan 12;276(2):1133-7. doi: 10.1074/jbc.M008965200. J Biol Chem. 2001. PMID: 11050102 Free article.

8

Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.

De Esch IJ, Mills JE, Perkins TD, Romeo G, Hoffmann M, Wieland K, Leurs R, Menge WM, Nederkoorn PH, Dean PM, Timmerman H. De Esch IJ, et al. Among authors: leurs r. J Med Chem. 2001 May 24;44(11):1666-74. doi: 10.1021/jm001109k. J Med Chem. 2001. PMID: 11356102

9

Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.

Bakker RA, Schoonus SB, Smit MJ, Timmerman H, Leurs R. Bakker RA, et al. Among authors: leurs r. Mol Pharmacol. 2001 Nov;60(5):1133-42. doi: 10.1124/mol.60.5.1133. Mol Pharmacol. 2001. PMID: 11641442

10

A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.

Booth RG, Moniri NH, Bakker RA, Choksi NY, Nix WB, Timmerman H, Leurs R. Booth RG, et al. Among authors: leurs r. J Pharmacol Exp Ther. 2002 Jul;302(1):328-36. doi: 10.1124/jpet.302.1.328. J Pharmacol Exp Ther. 2002. PMID: 12065734

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