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Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
Gauna C, Meyler FM, Janssen JA, Delhanty PJ, Abribat T, van Koetsveld P, Hofland LJ, Broglio F, Ghigo E, van der Lely AJ. Gauna C, et al. Among authors: meyler fm. J Clin Endocrinol Metab. 2004 Oct;89(10):5035-42. doi: 10.1210/jc.2004-0363. J Clin Endocrinol Metab. 2004. PMID: 15472202 Clinical Trial.